Demonstrating a Novel, Hidden Source of Spectral Distortion in X-ray Photon Counting Detectors and Assessing Novel Trigger Schemes Proposed to Avoid It

Author:

Pickford Scienti Oliver L. P. Pickford1ORCID,Darambara Dimitra G.1ORCID

Affiliation:

1. Joint Department of Physics, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London SM2 5NG, UK

Abstract

X-ray photon counting spectral imaging (x-CSI) determines a detected photon’s energy by comparing the charge it induces with several thresholds, counting how many times each is crossed (the standard method, STD). This paper is the first to demonstrate that this approach can unexpectedly delete counts from the recorded energy spectrum under some clinically relevant conditions: a process we call negative counting. Four alternative counting schemes are proposed and simulated for a wide range of sensor geometries (pixel pitch 100–600 µm, sensor thickness 1–3 mm), number of thresholds (3, 5, 8, 24 and 130) and medically relevant X-ray fluxes (106–109 photons mm−2 s−1). Spectral efficiency and counting efficiency are calculated for each simulation. Performance gains are explained mechanistically and correlated well with the improved suppression of “negative counting”. The best performing scheme (Shift Register, SR) entirely eliminates negative counting, remaining close to an ideal scheme at fluxes of up to 108 photons mm−2 s−1. At the highest fluxes considered, the deviation from ideal behaviour is reduced by 2/3 in SR compared with STD. The results have significant implications both for generally improving spectral fidelity and as a possible path toward the 109 photons mm−2 s−1 goal in photon-counting CT.

Funder

STFC Cancer Diagnosis Network+

NHS

Publisher

MDPI AG

Subject

Electrical and Electronic Engineering,Biochemistry,Instrumentation,Atomic and Molecular Physics, and Optics,Analytical Chemistry

Reference22 articles.

1. Siemens (2021, November 28). NAEOTOM Alpha® with Quantum Technology. Available online: https://www.siemens-healthineers.com/computed-tomography/photon-counting-ct-scanner/naeotom-alpha.

2. Photon-counting CT for simultaneous imaging of multiple contrast agents in the abdomen: An in vivo study;Symons;Med. Phys.,2017

3. MARS for Clinicians (2021, February 24). MARS Bioimaging Limited. Available online: https://www.marsbioimaging.com/clinicians/.

4. Evaluation of spectral photon counting computed tomography K-edge imaging for determination of gold nanoparticle biodistribution: In vivo;Cormode;Nanoscale,2017

5. GE Healthcare (2021, November 30). Karolinska Institutet & MedTechLabs Kickoff The World’s First Clinical Evaluation of GE Healthcare’s Photon Counting CT Technology with Deep Silicon Detectors. Available online: https://www.ge.com/news/press-releases/karolinska-institutet-medtechlabs-kickoff-the-worlds-first-clinical-evaluation-of-ge#_edn1.

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3