The Greifswald Post COVID Rehabilitation Study and Research (PoCoRe)–Study Design, Characteristics and Evaluation Tools

Author:

Steinmetz AnkeORCID,Bahlmann Susanne,Bergelt CorinnaORCID,Bröker Barbara M.,Ewert RalfORCID,Felix Stephan B.,Flöel Agnes,Fleischmann RobertORCID,Hoffmann Wolfgang,Holtfreter SilvaORCID,Nauck MatthiasORCID,Riemann Katja,Scheer ChristianORCID,Stahl Dana,Vogelgesang AntjeORCID,Völker Uwe,Wiesmann Ulrich,Klinger-König JohannaORCID,Walk René,Grabe Hans J.ORCID,Gross StefanORCID,Lehnert KristinORCID,Fielitz JensORCID,Dörr MarcusORCID

Abstract

(1) Background: COVID-19 is often associated with significant long-term symptoms and disability, i.e., the long/post-COVID syndrome (PCS). Even after presumably mild COVID-19 infections, an increasing number of patients seek medical help for these long-term sequelae, which can affect various organ systems. The pathogenesis of PCS is not yet understood. Therapy has so far been limited to symptomatic treatment. The Greifswald Post COVID Rehabilitation Study (PoCoRe) aims to follow and deeply phenotype outpatients with PCS in the long term, taking a holistic and comprehensive approach to the analysis of their symptoms, signs and biomarkers. (2) Methods: Post-COVID outpatients are screened for symptoms in different organ systems with a standardized medical history, clinical examination, various questionnaires as well as physical and cardiopulmonary function tests. In addition, biomaterials are collected for the analysis of immunomodulators, cytokines, chemokines, proteome patterns as well as specific (auto)antibodies. Patients are treated according to their individual needs, adhering to the current standard of care. PoCoRe’s overall aim is to optimize diagnostics and therapy in PCS patients.

Publisher

MDPI AG

Subject

General Medicine

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