Affiliation:
1. Department of Psychiatry, Wroclaw Medical University, 50-367 Wroclaw, Poland
2. Department of Clinical Pharmacology, Wroclaw Medical University, 50-367 Wroclaw, Poland
Abstract
Depression is a global mental health concern, and personalized treatment approaches are needed to optimize its management. This study aimed to investigate the influence of the CYP2D6 and CYP1A2 gene polymorphisms on the efficacy of duloxetine in reducing depressive and anxiety symptoms. A sample of 100 outpatients with major depression, who initiated monotherapy with duloxetine, were followed up. Polymorphisms in the CYP2D6 and CYP1A2 genes were assessed. The severity of depressive and anxiety symptoms was recorded using standardized scales. Adverse drug reactions (ADRs) were analyzed. Statistical analyses, including linear regression, were conducted to examine the relationships between genetic polymorphisms, clinical variables, and treatment outcomes. Patients with higher values of the duloxetine metabolic index (DMI) for CYP2D6, indicating a faster metabolism, achieved a greater reduction in anxiety symptoms. The occurrence of ADRs was associated with a lower reduction in anxiety symptoms. However, no significant associations were found between studied gene polymorphisms and reduction in depressive symptoms. No significant effects of the DMI for CYP1A2 were found. Patients with a slower metabolism may experience less benefit from duloxetine therapy in terms of anxiety symptom reduction. Personalizing treatment based on the CYP2D6 and CYP1A2 gene polymorphisms can enhance the effectiveness of antidepressant therapy and improve patient outcomes.
Funder
“Diamentowy Grant” program: “CYP 2D6 and CYP 1A2 polymorphisms and the efficacy and tolerability of duloxetine in the treatment of depression”
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
Reference40 articles.
1. Institute of Health Metrics and Evaluation (2023, July 08). Global Health Data Exchange (GHDx). Available online: https://vizhub.healthdata.org/gbd-results/.
2. Lopez, A.D., and Murray, C.J. (1996). The Global Burden of Disease: A Comprehensive Assessment of Mortality and Disability from Diseases, Injuries, and Risk Factors in 1990 and Projected to 2020, Harvard School of Public Health. Available online: https://apps.who.int/iris/handle/10665/41864.
3. Psychological autopsy studies of suicide: A systematic review;Cavanagh;Psychol. Med.,2003
4. If at first you don’t succeed: A review of the evidence for antidepressant augmentation, combination and switching strategies;Connolly;Drugs,2011
5. Diagnosis and definition of treatment-resistant depression;Fava;Biol. Psychiatry,2003
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献