The Enigma of Mammaglobin: Redefining the Biomarker Paradigm in Breast Carcinoma-Reference-Cited by-同舟云学术

The Enigma of Mammaglobin: Redefining the Biomarker Paradigm in Breast Carcinoma

Published:2023-08-29 Issue:17 Volume:24 Page:13407
ISSN:1422-0067
Container-title:International Journal of Molecular Sciences
language:en
Short-container-title:IJMS

Author:

Milosevic Bojan¹,Stojanovic Bojan¹^ORCID,Cvetkovic Aleksandar¹,Jovanovic Ivan²^ORCID,Spasic Marko¹^ORCID,Stojanovic Milica Dimitrijevic³,Stankovic Vesna³,Sekulic Marija⁴,Stojanovic Bojana S.²⁵,Zdravkovic Natasa⁶,Mitrovic Minja⁷,Stojanovic Jasmina⁸^ORCID,Laketic Darko⁹^ORCID,Vulovic Maja¹⁰,Cvetkovic Danijela¹¹^ORCID

Affiliation:

1. Department of Surgery, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia

2. Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia

3. Department of Pathology, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia

4. Department of Hygiene and Ecology, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia

5. Department of Pathophysiology, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia

6. Department of Internal Medicine, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia

7. Department of Neurology, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia

8. Department of Otorhinolaryngology, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia

9. Institute of Anatomy, Faculty of Medicine, University of Belgrade,11000 Belgrade, Serbia

10. Department of Anatomy, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia

11. Department of Genetics, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia

Abstract

The continuous evolution of cancer biology has led to the discovery of mammaglobin, a potential novel biomarker for breast carcinoma. This review aims to unravel the enigmatic aspects of mammaglobin and elucidate its potential role in redefining the paradigm of breast carcinoma biomarkers. We will thoroughly examine its expression in tumoral and peritumoral tissues and its circulating levels in the blood, thereby providing insights into its possible function in cancer progression and metastasis. Furthermore, the potential application of mammaglobin as a non-invasive diagnostic tool and a target for personalized treatment strategies will be discussed. Given the increasing incidence of breast carcinoma worldwide, the exploration of novel biomarkers such as mammaglobin is crucial in advancing our diagnostic capabilities and treatment modalities, ultimately contributing to improved patient outcomes.

Funder

Ministry of Science, Technological Development, and Innovation of the Republic of Serbia

Junior Project of the Faculty of Medical Sciences at the University of Kragujevac, Serbia

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

Link

https://www.mdpi.com/1422-0067/24/17/13407/pdf

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