DRP1 Regulation as a Potential Target in Hypoxia-Induced Cerebral Pathology-Reference-Cited by-同舟云学术

DRP1 Regulation as a Potential Target in Hypoxia-Induced Cerebral Pathology

Published:2023-12-09 Issue:4 Volume:4 Page:333-348
ISSN:2673-5261
Container-title:Journal of Molecular Pathology
language:en
Short-container-title:JMP

Author:

Fedorova Evgenia N.¹²,Egorova Anna V.¹²^ORCID,Voronkov Dmitry N.¹^ORCID,Mudzhiri Natalia M.¹²,Baranich Tatiana I.¹²,Glinkina Valeria V.²,Krapivkin Alexey I.³^ORCID,Mamedov Ilgar S.³^ORCID,Sukhorukov Vladimir S.¹²^ORCID

Affiliation:

1. Neuromorphology Laboratory of Brain Institute, Research Center of Neurology, 125367 Moscow, Russia

2. Department for Histology, Embryology, and Cytology, Pirogov Russian National Research Medical University, 117997 Moscow, Russia

3. Scientific Department, V.F. Voyno-Yasenetsky Scientific and Practical Center of Specialized Medical Care for Children, 119620 Moscow, Russia

Abstract

The following review considers current concepts concerning the characteristics of DRP1-related mitochondrial division in brain cells during hypoxic-ischemic pathology. The functional role of DRP1 in neurons and astroglia in cerebral ischemia conditions was analyzed. We discuss the potential for regulating DRP1 activity through the selective inhibitor of mitochondrial fission, mdivi-1. The article also presents data on DRP1 involvement in astro- and microglia-mediated intercellular mitochondrial transport. Understanding of the molecular mechanisms responsible for mitochondrial fission during hypoxic-ischemic exposure will allow us to consider DRP1 as an effective therapeutic target for treating conditions with a hypoxic component.

Funder

Fundamental aspects of neuroplasticity within a model of translational neuroscience

Publisher

MDPI AG

Subject

General Medicine

Link

https://www.mdpi.com/2673-5261/4/4/27/pdf

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