Mobilising Collaboration among Stakeholders to Optimise the Growing Potential of Data for Tackling Cancer

Author:

Horgan Denis12,Van den Bulcke Marc3,Malapelle Umberto4ORCID,Normanno Nicola5ORCID,Capoluongo Ettore D.67,Prelaj Arsela8ORCID,Rizzari Carmelo9ORCID,Stathopoulou Aliki10,Singh Jaya1,Kozaric Marta1,Dube France11,Ottaviano Manuel12,Boccia Stefania1314ORCID,Pravettoni Gabriella1516,Cattaneo Ivana17,Malats Núria18ORCID,Buettner Reinhard19ORCID,Lekadir Karim20,de Lorenzo Francesco10,Alix-Panabieres Catherine21ORCID,Badreh Sara22,Hofman Paul23ORCID,De Maria Ruggero24,Solary Eric252627ORCID

Affiliation:

1. European Alliance for Personalised Medicine, 1040 Brussels, Belgium

2. Department of Molecular and Cellular Engineering, Jacob Institute of Biotechnology and Bioengineering, Faculty of Engineering and Technology, Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagraj 211007, India

3. Belgian Cancer Centre, Sciensano, 1050 Brussels, Belgium

4. Department of Public Health, University Federico II of Naples, 80138 Naples, Italy

5. Istituto Nazionale Tumori “Fondazione G. Pascale”—IRCCS, 80131 Naples, Italy

6. Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, 80138 Naples, Italy

7. Department of Clinical Pathology and Genomics, Azienda Ospedaliera per L’Emergenza Cannizzaro, 95126 Catania, Italy

8. Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale Tumori, 20133 Milan, Italy

9. Unità di Ematologia Pediatrica, Fondazione MBBM, Università di Milano-Bicocca, 20126 Monza, Italy

10. European Cancer Patient Coalition, 1000 Brussels, Belgium

11. Astra Zeneca, Concord Pike, Wilmington, DE 19803, USA

12. Departamento de Tecnología Fotónica y Bioingeniería, Universidad Politècnica de Madrid, 28040 Madrid, Spain

13. Section of Hygiene, Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore, 20123 Rome, Italy

14. Departments of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy

15. Department of Oncology and Hemato-Oncology, University of Milan, 20122 Milan, Italy

16. Applied Research Division for Cognitive and Psychological Science, European Institute of Oncology (IEO) IRCCS, 20139 Milan, Italy

17. Novartis Farma SpA, 21042 Origgio, Italy

18. Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain

19. Lung Cancer Group Cologne, Institute of Pathology, Center for Integrated Oncology Cologne/Bonn, University Hospital Cologne, 50937 Cologne, Germany

20. Artificial Intelligence in Medicine Lab (BCN-AIM), Universitat de Barcelona, 08007 Barcelona, Spain

21. Laboratory of Rare Human Circulating Cells, University Medical Center of Montpellier, 34093 Montpellier, France

22. Cancer Childhood International, 1200 Vienna, Austria

23. Laboratory of Clinical and Experimental Pathology, Pasteur Hospital, Université Côte d’Azur, 06000 Nice, France

24. Institute of General Pathology, Catholic University of the Sacred Heart, 20123 Rome, Italy

25. INSERM U1287, Gustave Roussy Cancer Campus, 94805 Villejuif, France

26. Faculty of Medicine, Université Paris-Sud, Le Kremlin-Bicêtre, 91405 Orsay, France

27. Department of Hematology, Gustave Roussy Cancer Campus, 94805 Villejuif, France

Abstract

Effective cancer diagnosis, treatment and control depend on interactions among numerous distinct factors, from technology to data to skills to sociology. But a crucial influence is the extent to which the health system takes account of the distinct perspectives of the many different groups of interdependent stakeholders concerned with cancer, including patients, practitioners and planners. This paper provides some elucidation as to how far and how efficiently these interactions currently take place in Europe. It also makes some tentative suggestions as to how conscious systematic interventions could improve cancer outcomes. It is based on a series of expert panels and surveys conducted by the European Alliance for Personalised Medicine (EAPM) that provided information at the national level on three selected parameters: implementation of next-generation sequencing (NGS) and liquid biopsy (LB), attitudes of patients to prevention and practices of sharing genomic data among healthcare professionals (HCPs). The varying data infrastructure highlights the urgent need for substantial improvements to accommodate the increasing importance of genomics data in cancer diagnosis and care. Additionally, we identify disparities in age-specific approaches to cancer prevention, emphasising the necessity for tailored strategies to address unique age group perspectives. Moreover, distinct regional prioritizations in cancer treatment underscore the importance of considering regional variations when shaping future cancer care strategies. This study advocates for collaborative data sharing supported by technological innovation to overcome these challenges, ultimately fostering a holistic and equitable provision of cancer care in Europe.

Funder

Reducing Disparities Across the European Union

Publisher

MDPI AG

Subject

General Medicine

Reference44 articles.

1. European Commission (2023, June 07). ECIS—European Cancer Information System. Available online: https://ecis.jrc.ec.europa.eu/.

2. World Health Organization (2023, June 07). Cancer. Available online: https://www.who.int/news-room/fact-sheets/detail/cancer.

3. OECD (2023, March 29). EU Country Cancer Profiles. Available online: https://www.oecd-ilibrary.org/social-issues-migration-health/eu-country-cancer-profiles_55f07000-en.

4. The Lancet Oncology Commission European Groundshot-addressing Europe’s cancer research challenges: A Lancet Oncology Commission;Lawler;Lancet Oncol.,2022

5. The Oncology Data Network (ODN): A Collaborative European Data-Sharing Platform to Inform Cancer Care;Kerr;Oncologist,2020

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