Acute Psychological Stress Detection Using Explainable Artificial Intelligence for Automated Insulin Delivery

Abstract

Acute psychological stress (APS) is a complex and multifactorial phenomenon that affects metabolism, necessitating real-time detection and interventions to mitigate its effects on glycemia in people with type 1 diabetes. This study investigates the detection of APS using physiological variables measured by the Empatica E4 wristband and employs explainable machine learning to evaluate the importance of the physiological signals. The extreme gradient boosting model is developed for classification of APS and non-stress (NS) with weighted training, achieving an overall accuracy of 99.93%. The Shapley additive explanations (SHAP) technique is employed to interpret the global importance of the physiological signals, determining the order of importance for the variables from most to least as galvanic skin response (GSR), heart rate (HR), skin temperature (ST), and motion sensors (accelerometer readings). The increase in GSR and HR are positively correlated with the occurrence of APS as indicated by high positive SHAP values. The SHAP technique is also used to explain the local signal importance for particular instances of misclassified samples. The detection of APS can inform multivariable automated insulin delivery systems to intervene to counteract the APS-induced glycemic excursions in people with type 1 diabetes.