Successful Use of Continuous Veno-Venous Haemodialysis in a Case of Potential Lethal Caffeine Intoxication

Author:

Reimerink Elles J.1,Huntjens Daan W.2ORCID,Pelkmans Lindsey G.1,Geerts Jan-Willem H. J.1,Franssen Eric J. F.2

Affiliation:

1. Department of Intensive Care, OLVG Hospital, 1061 AE Amsterdam, The Netherlands

2. Department of Clinical Pharmacy, OLVG Hospital, 1061 AE Amsterdam, The Netherlands

Abstract

Here we describe the case of a potentially lethal caffeine intoxication after the reported ingestion of 10 g of caffeine. Due to hemodynamic instability with tachycardia and hypertension with an insufficient effect of continuous labetalol infusion, the patient was started on continuous veno-venous haemodialysis (CVVHD). After successful treatment for 15 h, CVVHD could be discontinued, and the patient was discharged home the next day. This case report is the first to report the use of CVVHD as a haemodialysis modality in the case of caffeine intoxication and illustrate the effect on caffeine clearance. We stress the importance of an early recognition of caffeine intoxication, so that haemodialysis can be considered in the case of a potentially lethal intoxication.

Publisher

MDPI AG

Subject

Chemical Health and Safety,Health, Toxicology and Mutagenesis,Toxicology

Reference21 articles.

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2. Jaspers, T.C.C., Ter Laak, M., and Kramers, C. (2019). Toxicologie Behandelinformatie: Monografie Coffeïne, Nationaal Vergiftigingen Informatie Centrum van het RIVM.

3. Haemodialysis in massive caffeine intoxication;Fausch;Clin. Kidney J.,2012

4. The clinical toxicology of caffeine: A review and case study;Willson;Toxicol. Rep.,2018

5. Caffeine: Cognitive and physical performance enhancer or psychoactive drug?;Cappelletti;Curr. Neuropharmacol.,2015

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