Affiliation:
1. Center for Gender Specific Medicine, Istituto Superiore di Sanità, 00161 Rome, Italy
2. Department of Biomedicine and Prevention, University of Rome “Tor Vergata”, 00173 Rome, Italy
3. Experimental Animal Welfare Sector, Istituto Superiore di Sanità, 00161 Rome, Italy
Abstract
Titanium dioxide (TiO2) nanomaterial is used in several items (implant materials, pills composition, cosmetics, etc.). Although TiO2 is no longer considered safe as a food additive, the general population is exposed daily through different routes, and information is lacking on some aspects of animal and human health. This study evaluated liver and kidney toxicity of food-grade TiO2 nanoparticles (NPs) (primary size < 25 nm) in male and female rats that were orally exposed for 5 days to 0, 1, and 2 mg/kg body weight per day (comparable with daily E171 consumption). Selected liver and kidney toxicity endpoints included serum biomarkers, histopathological analysis and expression of osteopontin (SPP1), vascular endothelial growth factor (VEGF), interleukin 6 (IL-6), and neuropeptide Y (NPY). Although TiO2 NPs are known to affect the gastric mucosa, short-term exposure induced sex-specific effects: general toxicity parameters were predominantly altered in female rats, whereas the liver appeared to be more affected than the kidneys in male rats, which also showed overexpression of NPY and SPP1. In the kidneys, the TiO2 NP effects were quantitatively similar but qualitatively different in the two sexes. In conclusion, careful consideration should be paid to the presence of TiO2 NPs in other items that can lead to human exposure.
Subject
Chemical Health and Safety,Health, Toxicology and Mutagenesis,Toxicology
Reference43 articles.
1. Mansoor, A., Khurshid, Z., Khan, M.T., Mansoor, E., Butt, F.A., Jamal, A., and Palma, P.J. (2022). Medical and Dental Applications of Titania Nanoparticles: An Overview. Nanomaterials, 12.
2. Recent advances in syntheses, properties and applications of TiO(2) nanostructures;Ali;RSC Adv.,2018
3. (2023, July 23). Titanium Dioxide: Are There Health Risks?. Available online: https://www.bfr.bund.de/en/titanium_dioxide__are_there_health_risks_-241091.html.
4. EFSA (2019). EFSA statement on the review of the risks related to the exposure to the food additive titanium dioxide (E 171) performed by the french agency for food, environmental and occupational health and safety (ANSES). EFSA J., 17, e05714.
5. Titanium dioxide nanoparticles in food and personal care products;Weir;Environ. Sci. Technol.,2012
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