Time Patterns in Internal Human Exposure Data to Bisphenols, Phthalates, DINCH, Organophosphate Flame Retardants, Cadmium and Polyaromatic Hydrocarbons in Europe-Reference-Cited by-同舟云学术

Time Patterns in Internal Human Exposure Data to Bisphenols, Phthalates, DINCH, Organophosphate Flame Retardants, Cadmium and Polyaromatic Hydrocarbons in Europe

Published:2023-09-28 Issue:10 Volume:11 Page:819
ISSN:2305-6304
Container-title:Toxics
language:en
Short-container-title:Toxics

Author:

Rodriguez Martin Laura¹^ORCID,Gilles Liese¹^ORCID,Helte Emilie²,Åkesson Agneta²^ORCID,Tägt Jonas²,Covaci Adrian³^ORCID,Sakhi Amrit K.⁴,Van Nieuwenhuyse An⁵^ORCID,Katsonouri Andromachi⁶^ORCID,Andersson Anna-Maria⁷⁸,Gutleb Arno C.⁹^ORCID,Janasik Beata¹⁰,Appenzeller Brice¹¹,Gabriel Catherine¹²¹³^ORCID,Thomsen Cathrine⁴,Mazej Darja¹⁴^ORCID,Sarigiannis Denis¹²¹³¹⁵,Anastasi Elena⁶,Barbone Fabio¹⁶,Tolonen Hanna¹⁷^ORCID,Frederiksen Hanne⁷^ORCID,Klanova Jana¹⁸,Koponen Jani¹⁷,Tratnik Janja Snoj¹⁴^ORCID,Pack Kim¹⁹,Gudrun Koppen¹,Ólafsdóttir Kristin²⁰^ORCID,Knudsen Lisbeth E.²¹^ORCID,Rambaud Loïc²²^ORCID,Strumylaite Loreta²³^ORCID,Murinova Lubica Palkovicova²⁴^ORCID,Fabelova Lucia²⁴^ORCID,Riou Margaux²²^ORCID,Berglund Marika²,Szabados Maté²⁵,Imboden Medea²⁶,Laeremans Michelle¹,Eštóková Milada²⁷,Janev Holcer Natasa²⁸²⁹^ORCID,Probst-Hensch Nicole²⁶,Vodrazkova Nicole³⁰,Vogel Nina¹⁹^ORCID,Piler Pavel¹⁸^ORCID,Schmidt Phillipp¹⁹^ORCID,Lange Rosa¹⁹,Namorado Sónia³¹^ORCID,Kozepesy Szilvia²⁵^ORCID,Szigeti Tamás²⁵^ORCID,Halldorsson Thorhallur I.²⁰^ORCID,Weber Till¹⁹,Jensen Tina Kold³²,Rosolen Valentina³³^ORCID,Puklova Vladimira³⁰^ORCID,Wasowicz Wojciech¹⁰,Sepai Ovnair³⁴,Stewart Lorraine³⁴,Kolossa-Gehring Marike¹⁹,Esteban-López Marta³⁵^ORCID,Castaño Argelia³⁵^ORCID,Bessems Jos¹^ORCID,Schoeters Greet¹³^ORCID,Govarts Eva¹

Affiliation:

1. VITO Health, Flemish Institute for Technological Research (VITO), 2400 Mol, Belgium

2. Institute of Environmental Medicine, Karolinska Institutet, 17177 Stockholm, Sweden

3. Toxicological Centre, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium

4. Norwegian Institute of Public Health, 0456 Oslo, Norway

5. Laboratoire National de Santé (LNS), Rue Louis Rech 1, 3555 Dudelange, Luxembourg

6. State General Laboratory, Ministry of Health, 2081 Nicosia, Cyprus

7. Department of Growth and Reproduction, Copenhagen University Hospital, Rigshospitalet, 2100 Copenhagen, Denmark

8. International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), University of Copenhagen, Rigshospitalet, 2100 Copenhagen, Denmark

9. Luxembourg Institute of Science and Technology (LIST), 4362 Esch-sur-Alzette, Luxembourg

10. Nofer Institute of Occupational Medicine, 91-348 Lodz, Poland

11. Luxembourg Institute of Health (LIH), 1445 Strassen, Luxembourg

12. Environmental Engineering Laboratory, Department of Chemical Engineering, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece

13. HERACLES Research Center on the Exposome and Health, Center for Interdisciplinary Research and Innovation, Balkan Center, Bldg. B, 10th km Thessaloniki-Thermi Road, 57001 Thessaloniki, Greece

14. Jožef Stefan Institute, 1000 Ljubljana, Slovenia

15. Environmental Health Engineering, Institute of Advanced Study, Palazzo del Broletto–Piazza Della Vittoria 15, 27100 Pavia, Italy

16. Department of Medicine, Surgery and Health Sciences, University of Trieste, Strada di Fiume, 447, 34149 Trieste, Italy

17. Finnish Institute for Health and Welfare (THL), 00271 Helsinki, Finland

18. RECETOX, Faculty of Science, Masaryk University, Kotlarska 2, 625 00 Brno, Czech Republic

19. Department of Toxicology, Health-Related Environmental Monitoring, German Environment Agency (UBA), 14195 Berlin, Germany

20. Faculty of Food Science and Nutrition, University of Iceland, Hofsvallagata 53, 107 Reykjavik, Iceland

21. Section of Environmental Health, University of Copenhagen, 1165 Copenhagen, Denmark

22. Department of Environmental and Occupational Health, Santé Publique France, 94410 Saint Maurice, France

23. Neuroscience Institute, Medical Academy, Lithuanian University of Health Sciences, LT-50161 Kaunas, Lithuania

24. Department of Environmental Medicine, Faculty of Public Health, Slovak Medical University, 833 03 Bratislava, Slovakia

25. National Public Health Center, Albert Florian 2-6, 1097 Budapest, Hungary

26. Swiss Tropical and Public Health Institute, Kreuzstrasse 2, 4123 Allschwil, Switzerland

27. Department of Environment and Health, Public Health Authority, 83105 Bratislava, Slovakia

28. Division for Environmental Health, Croatian Institute of Public Health, Rockefellerova 7, 10000 Zagreb, Croatia

29. Department of Social Medicine and Epidemiology, Faculty of Medicine, University of Rijeka, Bráce Branchetta 20/1, 51000 Rijeka, Croatia

30. Centre for Health and Environment, National Institute of Public Health, 100 00 Prague, Czech Republic

31. Department of Epidemiology, National Institute of Health Doctor Ricardo Jorge, Avenida Padre Cruz, 1649-016 Lisbon, Portugal

32. Department of Clinical Pharmacology, Pharmacy and Environmental Medicine, University of Southern Denmark, 5000 Odense, Denmark

33. Central Directorate for Health, Social Policies and Disability, Friuli Venezia Giulia Region, Via Cassa di Risparmio 10, 34121 Trieste, Italy

34. UKHSA UK Health Security Agency, Harwell Science Park, Chilton OX11 0RQ, UK

35. National Centre for Environmental Health, Instituto de Salud Carlos III, 28220 Majadahonda, Spain

Abstract

Human biomonitoring (HBM) data in Europe are often fragmented and collected in different EU countries and sampling periods. Exposure levels for children and adult women in Europe were evaluated over time. For the period 2000–2010, literature and aggregated data were collected in a harmonized way across studies. Between 2011–2012, biobanked samples from the DEMOCOPHES project were used. For 2014–2021, HBM data were generated within the HBM4EU Aligned Studies. Time patterns on internal exposure were evaluated visually and statistically using the 50th and 90th percentiles (P50/P90) for phthalates/DINCH and organophosphorus flame retardants (OPFRs) in children (5–12 years), and cadmium, bisphenols and polycyclic aromatic hydrocarbons (PAHs) in women (24–52 years). Restricted phthalate metabolites show decreasing patterns for children. Phthalate substitute, DINCH, shows a non-significant increasing pattern. For OPFRs, no trends were statistically significant. For women, BPA shows a clear decreasing pattern, while substitutes BPF and BPS show an increasing pattern coinciding with the BPA restrictions introduced. No clear patterns are observed for PAHs or cadmium. Although the causal relations were not studied as such, exposure levels to chemicals restricted at EU level visually decreased, while the levels for some of their substitutes increased. The results support policy efficacy monitoring and the policy-supportive role played by HBM.

Funder

Horizon 2020

Publisher

MDPI AG

Subject

Chemical Health and Safety,Health, Toxicology and Mutagenesis,Toxicology

Link

https://www.mdpi.com/2305-6304/11/10/819/pdf

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