Oxidative Stress Effects of Multiple Pollutants in an Indoor Environment on Human Bronchial Epithelial Cells

Author:

Cheng Yao1,Kong Dexuan2,Ci Meng3,Guan Yunlong1,Luo Changyi24,Zhang Xianglan1,Gao Fuping2,Li Min2,Deng Gaofeng1

Affiliation:

1. State Key Laboratory of Building Safety and Environment, China Academy of Building Research, Beijing 100013, China

2. Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China

3. China National Accreditation Insitute of Conformity Assessment, Beijing 100010, China

4. Beijing Institute of Basic Medical Sciences, Beijing 100850, China

Abstract

Benzene, toluene, and xylene (denoted as BTX) are normally used in coatings, sealants, curing agents and other home decoration products, which can cause harm to human health. However, traditional studies mostly focus on the toxicity evaluation of a single pollution source, and little attention has been paid to the toxicity reports of multiple pollutants in a complex system. To evaluate the impact of indoor BTX on human health at the cellular level, the oxidative stress effect of BTX on human bronchial epithelial cells was assessed, including cell cytotoxicity, intracellular ROS, cell mitochondrial membrane potential, cell apoptosis, and CYP2E1 expression. The concentrations of BTX introduced into the human bronchial epithelial cell culture medium were determined based on both the tested distribution in 143 newly decorated rooms and the limited concentrations in the indoor air quality (denoted as IAQ) standards. Our study showed that the concentration in line with the standard limit may still pose a serious risk to health. The cellular biology effect studies of BTX showed that BTX, even at concentrations lower than the national standard limit, can still induce observable oxidative stress effects which warrant attention.

Funder

Opening Funds of State Key Laboratory of Building Safety and Built Environment

National Natural Science Foundation of China

Publisher

MDPI AG

Subject

Chemical Health and Safety,Health, Toxicology and Mutagenesis,Toxicology

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