Affiliation:
1. Department of Epidemiology, The Geisel School of Medicine at Dartmouth, Lebanon, NH 03755, USA
2. Division of Laboratory Sciences, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
Abstract
Per- and polyfluoroalkyl substances (PFAS), widely used in industrial and consumer products, are suspected metabolic disruptors. We examined the association between a PFAS mixture during pregnancy and postpartum weight retention in 482 participants from the New Hampshire Birth Cohort Study. PFAS concentrations, including perfluorohexane sulfonate, perfluorooctane sulfonate (PFOS), perfluorooctanoate (PFOA), perfluorononanoate (PFNA), and perfluorodecanoate, were quantified in maternal plasma collected at ~28 gestational weeks. Postpartum weight change was calculated as the difference between self-reported weight from a postpartum survey administered in 2020 and pre-pregnancy weight abstracted from medical records. Associations between PFAS and postpartum weight change were examined using Bayesian kernel machine regression and multivariable linear regression, adjusting for demographic, reproductive, dietary, and physical activity factors; gestational week of blood sample collection; and enrollment year. PFOS, PFOA, and PFNA were positively associated with postpartum weight retention, and associations were stronger among participants with a higher pre-pregnancy body mass index. A doubling of PFOS, PFOA, and PFNA concentrations was associated with a 1.76 kg (95%CI: 0.31, 3.22), 1.39 kg (−0.27, 3.04), and 1.04 kg (−0.19, 2.28) greater postpartum weight retention, respectively, among participants who had obesity/overweight prior to pregnancy. Prenatal PFAS exposure may be associated with increased postpartum weight retention.
Funder
National Institutes of Health
National Institute of Environmental Health Sciences
National Institute of General Medical Sciences
NIEHS Pathway to Independence Award
Subject
Chemical Health and Safety,Health, Toxicology and Mutagenesis,Toxicology
Reference50 articles.
1. Hales, C.M., Carroll, M.D., Fryar, C.D., and Ogden, C.L. (2020). Prevalence of Obesity and Severe Obesity among Adults: United States, 2017–2018. NCHS Data Brief, 1–8.
2. Impact of Maternal Obesity on Perinatal and Childhood Outcomes;Santangeli;Best Pract. Res. Clin. Obstet. Gynaecol.,2015
3. Pregnancy: A Stress Test for Life;Williams;Curr. Opin. Obstet. Gynecol.,2003
4. Influence of Maternal Obesity on the Long-Term Health of Offspring;Godfrey;Lancet Diabetes Endocrinol.,2017
5. Pregnancy as a Risk Factor for Obesity: Lessons from the Stockholm Pregnancy and Weight Development Study;Ohlin;Obes. Res.,1995
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献