Estimation of the Dietary Acrylamide Exposure of the Turkish Population: An Emerging Threat for Human Health

Author:

Basaran Burhan1ORCID

Affiliation:

1. Department of Nutrition and Dietetics, Faculty of Health Sciences, Recep Tayyip Erdogan University, Rize 53100, Türkiye

Abstract

Acrylamide is a contaminant formed during heat treatment that poses potential health risks and occurs naturally in foods. Therefore, it is crucial to evaluate exposure from the consumption of foods containing acrylamide since dietary exposure continues throughout life. In this study, the acrylamide exposure level of people living in Türkiye is estimated. Consumption of a total of 28 foods in 9 different food groups was calculated using a deterministic model under two different scenarios. The exposure levels were evaluated in terms of carcinogenic, non-carcinogenic and neurotoxic health risks. The daily total acrylamide exposure levels of individuals aged 15 and older were determined as 58 µg/day (0.85 µg/kg bw/day) and 196 µg/day (2.80 µg/kg bw/day) for the good and bad scenarios, respectively. The highest daily acrylamide exposure in the good scenario came from brewed black tea (29%), whereas French fries (50%) were the source of highest daily acrylamide exposure in the bad scenario. According to the hazard index (HI) and margin of exposure (MOE) data, the good scenario (all food) is considered safe, while the bad scenario (all food) has potential and serious health risks. According to the carcinogenic risk (CR) data, both scenarios carry significant health risks. It is therefore important that consumers, producers and official institutions collaborate and take measures to reduce acrylamide exposure.

Publisher

MDPI AG

Reference82 articles.

1. National Center for Biotechnology Information (2024, June 12). PubChem Compound Summary for CID 6579, Acrylamide, Available online: https://pubchem.ncbi.nlm.nih.gov/compound/Acrylamide.

2. Akagi, J.-I., Yokoi, M., Miyake, Y., Shirai, T., Baba, T., Cho, Y.-M., Hanaoka, F., Sugasawa, K., Iwai, S., and Ogawa, K. (2023). A formamidopyrimidine derivative from the deoxyguanosine adduct produced by food contaminant acrylamide induces DNA replication block and mutagenesis. J. Biol. Chem., 299.

3. International Agency for Research on Cancer (2024, July 08). IARC Monographs on the Identification of Carcinogenic Hazards to Humans. List of Classifications. In Agents Classified by the IARC Monographs; Volume 1–129. Available online: https://monographs.iarc.who.int/list-of-classifications/.

4. European Commission (2024, February 12). Regulation (EC) No 1272/2008 of the European Parliament and of the Council of 16 December 2008 on Classification, Labelling and Packaging of Substances and Mixtures, Amending and Repealing Directives 67/548/EEC and 1999/45/EC, and Amending Regulation (EC) No 1907/2006 (Text with EEA Relevance). Available online: https://eur-lex.europa.eu/legal-content/EN/TXT/PDF/?uri=CELEX:32008R1272.

5. European Chemical Agency (2024, July 23). Candidate List of Substances of very High Concern for Authorization. Available online: https://echa.europa.eu/-/acrylamide-included-in-the-reach-candidate-list-of-substances-of-very-high-concern-for-authorisation.

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3