Vitamin A Status in Preterm Infants Is Associated with Inflammation and Dexamethasone Exposure
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Published:2023-01-14
Issue:2
Volume:15
Page:441
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ISSN:2072-6643
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Container-title:Nutrients
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language:en
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Short-container-title:Nutrients
Author:
Rossholt Madelaine Eloranta,Wendel Kristina,Bratlie Marianne,Aas Marlen Fossan,Gunnarsdottir Gunnthorunn,Fugelseth Drude,Pripp Are Hugo,Domellöf Magnus,Størdal Ketil,Stiris Tom,Moltu Sissel Jennifer
Abstract
Vitamin A has a key role in lung development and its deficiency is associated with an increased risk of bronchopulmonary dysplasia. This secondary cohort analysis of the ImNuT trial (Immature, Nutrition Therapy NCT03555019) aimed to (1) explore vitamin A status in preterm infants <29 weeks gestation and (2) assess the influence of inflammation and postnatal dexamethasone exposure on vitamin A concentrations in blood. We report detailed information on vitamin A biochemistry, vitamin A intake, markers of inflammation and dexamethasone exposure. After four weeks of age, infants exposed to dexamethasone (n = 39) showed higher vitamin A concentrations compared to unexposed infants (n = 41); median (IQR) retinol was 1.0 (0.74, 1.5) vs. 0.56 (0.41, 0.74) µmol/L, p < 0.001. Pretreatment retinol concentrations were lower in the dexamethasone group compared to non-exposed infants (p < 0.001); 88% vs. 60% of the infants were considered deficient in vitamin A (retinol < 0.7 µmol/L) at one week of age. Small size for gestational age, mechanical ventilation and elevated levels of interleukin-6 were factors negatively associated with first-week retinol concentrations. In conclusion, preterm infants <29 weeks gestation are at risk of vitamin A deficiency despite intakes that accommodate current recommendations. The presence of inflammation and dexamethasone exposure should be considered when interpreting vitamin A status.
Funder
Research Council of Norway
Oslo University Hospital
Norwegian Association of the Blind and Partially Sighted
Subject
Food Science,Nutrition and Dietetics
Cited by
1 articles.
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