Glioblastoma Treatment: State-of-the-Art and Future Perspectives

Author:

Rodríguez-Camacho AlejandroORCID,Flores-Vázquez José GuillermoORCID,Moscardini-Martelli JúliaORCID,Torres-Ríos Jorge Alejandro,Olmos-Guzmán AlejandroORCID,Ortiz-Arce Cindy SharonORCID,Cid-Sánchez Dharely Raquel,Pérez Samuel Rosales,Macías-González Monsserrat Del Sagrario,Hernández-Sánchez Laura Crystell,Heredia-Gutiérrez Juan Carlos,Contreras-Palafox Gabriel Alejandro,Suárez-Campos José de Jesús Emilio,Celis-López Miguel Ángel,Gutiérrez-Aceves Guillermo Axayacalt,Moreno-Jiménez Sergio

Abstract

(1) Background: Glioblastoma is the most frequent and lethal primary tumor of the central nervous system. Through many years, research has brought various advances in glioblastoma treatment. At this time, glioblastoma management is based on maximal safe surgical resection, radiotherapy, and chemotherapy with temozolomide. Recently, bevacizumab has been added to the treatment arsenal for the recurrent scenario. Nevertheless, patients with glioblastoma still have a poor prognosis. Therefore, many efforts are being made in different clinical research areas to find a new alternative to improve overall survival, free-progression survival, and life quality in glioblastoma patients. (2) Methods: Our objective is to recap the actual state-of-the-art in glioblastoma treatment, resume the actual research and future perspectives on immunotherapy, as well as the new synthetic molecules and natural compounds that represent potential future therapies at preclinical stages. (3) Conclusions: Despite the great efforts in therapeutic research, glioblastoma management has suffered minimal changes, and the prognosis remains poor. Combined therapeutic strategies and delivery methods, including immunotherapy, synthetic molecules, natural compounds, and glioblastoma stem cell inhibition, may potentiate the standard of care therapy and represent the next step in glioblastoma management research.

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

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