Abietane Diterpenoids from the Bark of Cryptomeria japonica and Their Antifungal Activities against Wood Decay Fungi-Reference-Cited by-同舟云学术

Abietane Diterpenoids from the Bark of Cryptomeria japonica and Their Antifungal Activities against Wood Decay Fungi

Published:2024-04-25 Issue:9 Volume:13 Page:1197
ISSN:2223-7747
Container-title:Plants
language:en
Short-container-title:Plants

Author:

Chang Chi-I¹²,Chen Cheng-Chi³,Wang Sheng-Yang⁴⁵^ORCID,Kuo Yueh-Hsiung⁶⁷⁸^ORCID

Affiliation:

1. Department of Biological Science and Technology, National Pingtung University of Science and Technology, Pingtung 912, Taiwan

2. Traditional Herbal Medicine Research Center, Taipei Medical University Hospital, Taipei 110, Taiwan

3. Department of Chemistry, National Taiwan University, Taipei 106, Taiwan

4. Department of Forestry, National Chung-Hsing University, Taichung 402, Taiwan

5. Agricultural Biotechnology Research Center, Academia Sinica, Taipei 115, Taiwan

6. Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung 404, Taiwan

7. Department of Biotechnology, Asia University, Taichung 413, Taiwan

8. Chinese Medicine Research Center, China Medical University, Taichung 404, Taiwan

Abstract

Phytochemical investigation of the bark of Cryptomeria japonica led to the isolation of five new abietane diterpenoids, 5-epi-12-hydroxy-6-nor-5,6-secoabieta-8,11,13-trien-7,5-olide (1), 12-hydroxy-6β-methoxy-6,7-secoabieta-8,11,13-trien-7,6-olide (2), 6β,12-dihydroxy-7,8-secoabieta-8,11,13-trien-7,8-olide (4), 5,12-dihydroxy-7,8-secoabieta-8,11,13-trien-7,8-olide (5), and 5α,8-epoxy-12-hydroxy-7,8-secoabieta-8,11,13-trien-7-al (6), together with one known abietane diterpenoid, obtuanhydride (3). Their structures were elucidated by analysis of spectroscopic data and comparison with the spectral data of known analogs. At the concentration of 100 μg/mL, compounds 4, 5, and 6 inhibited antifungal activities against wood decay fungi activity by 18.7, 37.2, and 46.7%, respectively.

Publisher

MDPI AG

Link

https://www.mdpi.com/2223-7747/13/9/1197/pdf

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