Affiliation:
1. Guangdong Provincial Key Laboratory IRADS and Department of Life Sciences, BNU-HKBU United International College, Zhuhai 519087, China
Abstract
Obesity has emerged as a significant health concern, as it is a disease linked to metabolic disorders in the body and is characterized by the excessive accumulation of lipids. As a plant-derived food, Platycodon grandiflorum (PG) was reported by many studies, indicating that the saponins from PG can improve obesity effectively. However, the anti-obesity saponins from PG and its anti-obesity mechanisms have not been fully identified. This study identified the active saponins and their molecular targets for treating obesity. The TCMSP database was used to obtain information on 18 saponins in PG. The anti-obesity target of the PG saponins was 115 targets and 44 core targets. GO and KEGG analyses using 44 core anti-obesity genes and targets of PG-active saponins screened from GeneCards, OMIM, Drugbank, and DisGeNet showed that the PI3K-Akt pathway, the JAK-STAT pathway, and the MAPK pathway were the major pathways involved in the anti-obesity effects of PG saponins. BIOVIA Discovery Studio Visualizer and AutoDock Vina were used to perform molecular docking and process the molecular docking results. The molecular docking results showed that the active saponins of PG could bind to the major therapeutic obesity targets to play an obesity-inhibitory role. The results of this study laid the foundation for further research on the anti-obesity saponins in PG and their anti-obesity mechanism and provided a new direction for the development of functional plant-derived food. This research studied the molecular mechanism of PG saponins combating obesity through various signaling pathways, and prosapogenin D can be used to develop as a new potential anti-obesity drug.
Funder
BNU-HKBU United International College, China
Guangdong Provincial Key Laboratory IRADS
Reference78 articles.
1. Has the prevalence of overweight, obesity and central obesity levelled off in the United States? Trends, patterns, disparities, and future projections for the obesity epidemic;Wang;Int. J. Epidemiol.,2020
2. Wong, J.C., O’Neill, S., Beck, B.R., Forwood, M.R., and Khoo, S.K. (2021). Comparison of obesity and metabolic syndrome prevalence using fat mass index, body mass index and percentage body fat. PLoS ONE, 16.
3. The causes of obesity: An in-depth review;Omer;Adv. Obes. Weight Manag. Control,2020
4. Adipaging’: Ageing and obesity share biological hallmarks related to a dysfunctional adipose tissue;Emanuele;J. Physiol.,2016
5. Obesity phenotypes, diabetes, and cardiovascular diseases;Tchernof;Circ. Res.,2020
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