Romanian Wild-Growing Chelidonium majus—An Emerging Approach to a Potential Antimicrobial Engineering Carrier System Based on AuNPs: In Vitro Investigation and Evaluation

Author:

Segneanu Adina-Elena1ORCID,Vlase Gabriela12ORCID,Vlase Titus12ORCID,Ciocalteu Maria-Viorica3,Bejenaru Cornelia3,Buema Gabriela4,Bejenaru Ludovic Everard3,Boia Eugen Radu5,Dumitru Andrei6,Boia Simina7ORCID

Affiliation:

1. Institute for Advanced Environmental Research-West, University of Timisoara (ICAM-WUT), Oituz nr. 4, 300223 Timisoara, Romania

2. Research Center for Thermal Analysis for Environmental Problems, West University of Timisoara, Pestalozzi St. 16, 300115 Timisoara, Romania

3. Faculty of Pharmacy, University of Medicine and Pharmacy Craiova, St. Petru Rareș 2, 200349 Craiova, Romania

4. National Institute of Research and Development for Technical Physics, 47 Mangeron Blvd., 700050 Iasi, Romania

5. Department of Ear, Nose, and Throat, Faculty of Medicine, “Victor Babeș” University of Medicine and Pharmacy Timisoara, 2 Eftimie Murgu Sq., 300041 Timisoara, Romania

6. Faculty of Sciences, Physical Education and Informatics—Department of Medical Assistance and Physiotherapy, National University for Science and Technology Politehnica Bucharest, University Center of Pitesti, St. Targu din Vale 1, 110040 Pitesti, Romania

7. Department of Periodontology, Faculty of Dental Medicine, Anton Sculean Research Center for Periodontal and Peri-Implant Diseases, “Victor Babeș” University of Medicine and Pharmacy Timisoara, 2 Eftimie Murgu Sq., 300041 Timisoara, Romania

Abstract

Novel nanotechnology based on herbal products aspires to be a high-performing therapeutic platform. This study reports the development of an original engineering carrier system that jointly combines the pharmacological action of Chelidonium majus and AuNPs, with unique properties that ensure that the limitations imposed by low stability, toxicity, absorption, and targeted and prolonged release can be overcome. The metabolite profile of Romanian wild-grown Chelidonium majus contains a total of seventy-four phytochemicals belonging to eight secondary metabolite categories, including alkaloids, amino acids, phenolic acids, flavonoids, carotenoids, fatty acids, sterols, and miscellaneous others. In this study, various techniques (XRD, FTIR, SEM, DLS, and TG/DTG) were employed to investigate his new carrier system’s morpho-structural and thermal properties. In vitro assays were conducted to evaluate the antioxidant potential and release profile. The results indicate 99.9% and 94.4% dissolution at different pH values for the CG-AuNPs carrier system and 93.5% and 85.26% for greater celandine at pH 4 and pH 7, respectively. Additionally, three in vitro antioxidant assays indicated an increase in antioxidant potential (flavonoid content 3.8%; FRAP assay 24.6%; and DPPH 24.4%) of the CG-AuNPs carrier system compared to the herb sample. The collective results reflect the system’s promising perspective as a new efficient antimicrobial and anti-inflammatory candidate with versatile applications, ranging from target delivery systems, oral inflammation (periodontitis), and anti-age cosmetics to extending the shelf lives of products in the food industry.

Publisher

MDPI AG

Reference96 articles.

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