A 21-Day Individual Rehabilitation Exercise Training Program Changes Irisin, Chemerin, and BDNF Levels in Patients after Hip or Knee Replacement Surgery-Reference-Cited by-同舟云学术

A 21-Day Individual Rehabilitation Exercise Training Program Changes Irisin, Chemerin, and BDNF Levels in Patients after Hip or Knee Replacement Surgery

Published:2023-07-25 Issue:15 Volume:12 Page:4881
ISSN:2077-0383
Container-title:Journal of Clinical Medicine
language:en
Short-container-title:JCM

Author:

Skrzep-Poloczek Bronisława¹^ORCID,Idzik Maciej²,Michalczyk Katarzyna¹,Chełmecka Elżbieta³^ORCID,Kukla Michał⁴⁵,Zalejska-Fiolka Jolanta⁶^ORCID,Poloczek Jakub⁷,Bogielski Bartosz¹,Jochem Jerzy¹,Nowak Damian¹,Stygar Dominika¹⁸

Affiliation:

1. Department of Physiology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Jordana 19 Street, 41-808 Zabrze, Poland

2. Independent Public Health Care, Opole Cancer Center Prof. Tadeusz Koszarowski, Katowicka 45-061 Street, 46-020 Opole, Poland

3. Department of Statistics, Department of Instrumental Analysis, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, Ostrogórska 31 Street, 41-200 Sosnowiec, Poland

4. Department of Internal Medicine and Geriatrics, Jagiellonian University Medical College in Cracow, Jakubowskiego 28 Street, 31-501 Cracow, Poland

5. Department of Endoscopy, University Hospital in Cracow, Jakubowskiego 28 Street, 31-501 Cracow, Poland

6. Department of Biochemistry, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Jordana 19 Street, 41-808 Zabrze, Poland

7. Department of Rehabilitation, 3rd Specialist Hospital in Rybnik, Energetyków 46 Street, 44-200 Rybnik, Poland

8. SLU University Animal Hospital, Swedish University of Agricultural Sciences, SE-750 07 Uppsala, Sweden

Abstract

Osteoarthritis (OA) is the most frequent worldwide cause of adult population disabilities. The study evaluated the effects of a 21-day individual rehabilitation exercise training program focused on improving patients’ functional capacity. The study analyzed the changes in irisin, chemerin, and BDNF serum levels in 36 OA patients subjected to an individually-adjusted rehabilitation program 90 days after surgical hip or knee replacement. The changes in irisin, chemerin, and BDNF serum levels were measured using enzyme-linked immunosorbent assay (ELISA) kits. A 21-day individual rehabilitation exercise training program significantly increased irisin and BDNF, and decreased chemerin serum levels. The presented study indicates that individually-adjusted exercise training is an important modulator influencing serum levels of anti- and pro-inflammatory factors, leading to positive clinical outcomes in osteoarthritis therapy. Selected factors are considered potential markers of various pathophysiological conditions. The presented study brings new details to the discussion.

Funder

Medical University of Silesia

Publisher

MDPI AG

Subject

General Medicine

Link

https://www.mdpi.com/2077-0383/12/15/4881/pdf

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