1. OCDEM Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LE, UK
2. Department of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy
3. Department of Surgery, Sapienza University of Rome, 00161 Rome, Italy
4. Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, UK