Author:
Sun Jiaming,Jia Keli,Sun Mingtao,Zhang Xianqiang,Chen Jinhong,Zhu Guohui,Li Changjiang,Lian Bo,Du Zhongde,Sun Hongwei,Sun Lin
Abstract
Background: Post-Traumatic Stress Disorder (PTSD) is a severe psychological disorder characterized by intrusive thoughts, heightened arousal, avoidance, and flashbacks. Cognitive flexibility dysfunction has been linked with the emergence of PTSD, including response inhibition deficits and impaired attentional switching, which results in difficulties for PTSD patients when disengaging attention from trauma-related stimuli. However, the molecular mechanisms of cognitive flexibility deficits remain unclear. Methods: The animals were exposed to a single prolonged stress and electric foot shock (SPS&S) procedure to induce PTSD-like features. Once the model was established, the changes in cognitive flexibility were assessed using an attentional set-shifting task (ASST) in order to investigate the effects of traumatic stress on cognitive flexibility. Additionally, the molecular alterations of certain proteins (AMPA Receptor 1 (GluA1), brain-derived neurotrophic factor (BDNF), and Postsynaptic density protein 95 (PSD95) in the medial prefrontal cortex (mPFC) were measured using Western blot and immunofluorescence. Results: The SPS&S model exhibited PTSD-like behaviors and induced reversal learning and set-shifting ability deficit in the ASST. These behavioral changes are accompanied by decreased GluA1, BDNF, and PSD95 protein expression in the mPFC. Further analysis showed a correlative relationship between the behavioral and molecular alterations. Conclusions: The SPS&S model induced cognitive flexibility deficits, and the potential underlying mechanism could be mediated by GluA1-related BDNF signaling in the mPFC.
Funder
The Education and Teaching Reform Project of the Psychology and Education Reference Committee of the Ministry of Education
the National Natural Science Foundation of China
Surface project of Natural Science Foundation of Shandong Province
Institute of Psychology, Chinese Academy of Sciences
Medical Education Research project of Chinese Medical Association
Science and Technology Development Program of Traditional Chinese Medicine in Shandong Province
Science and Technology Development Program in Weifang City
Cited by
3 articles.
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