Abstract
MicroRNAs (miRs) are promising diagnostic, prognostic and therapeutic biomolecules for atherosclerotic cardiovascular disease. Atherosclerotic occlusive disease concerns a large population of patients, carrying the highest incidence of fatal and non-fatal adverse events, such as myocardial infarction, ischemic stroke, and limb ischemia, worldwide. Consistently, miRs are involved in regulation and pathogenesis of atherosclerotic coronary artery disease (CAD), acute coronary syndromes (ACS), both with ST-segment (STEMI) and non-ST segment elevation myocardial infarctions (NSTEMI), as well as cardiac remodeling and fibrosis following ACS. However, the genetic and molecular mechanisms underlying adverse outcomes in CAD are multifactorial, and sometimes difficult to interpret for clinicians. Therefore, in the present review paper we have focused on the clinical meaning and the interpretation of various miRs findings, and their potential application in routine clinical practice.
Funder
Jagiellonian University
the John Paul II Hospital, Cracow, Poland
Reference167 articles.
1. Tanase, D.M., Gosav, E.M., Ouatu, A., Badescu, M.C., Dima, N., Ganceanu-Rusu, A.R., Popescu, D., Floria, M., Rezus, E., and Rezus, C. (2021). Current Knowledge of MicroRNAs (miRNAs) in Acute Coronary Syndrome (ACS): ST-Elevation Myocardial Infarction (STEMI). Life, 11.
2. Ren, J., Zhang, J., Xu, N., Han, G., Geng, Q., Song, J., Li, S., Zhao, J., and Chen, H. (2013). Signature of circulating microRNAs as po-tential biomarkers in vulnerable coronary artery disease. PLoS ONE, 8.
3. Circulating miRNA levels differ with respect to carotid plaque characteristics and symptom occurrence in patients with carotid artery stenosis and provide information on future cardiovascular events;Badacz;Adv. Interv. Cardiol.,2018
4. Kabłak-Ziembicka, A., and Przewłocki, T. (2021). Clinical Significance of Carotid Intima-Media Complex and Carotid Plaque As-sessment by Ultrasound for the Prediction of Adverse Cardiovascular Events in Primary and Secondary Care Patients. J. Clin. Med., 10.
5. 2017 ESC Guidelines on the Diagnosis and Treatment of Peripheral Arterial Diseases, in collaboration with the European Society for Vascular Surgery (ESVS): Document covering atherosclerotic disease of extracranial carotid and vertebral, mesenteric, renal, upper and lower extremity arteries Endorsed by: The European Stroke Organization (ESO) The Task Force for the Diagnosis and Treatment of Peripheral Arterial Diseases of the European Society of Cardiol-ogy (ESC) and of the European Society for Vascular Surgery (ESVS);Aboyans;Eur. Heart J.,2018
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