Abstract
Acute kidney injury (AKI) is becoming a public health problem worldwide. AKI is usually considered a complication of lung, heart, liver, gut, and brain disease, but recent findings have supported that injured kidney can also cause dysfunction of other organs, suggesting organ crosstalk existence in AKI. However, the organ crosstalk in AKI and the underlying mechanisms have not been broadly reviewed or fully investigated. In this review, we summarize recent clinical and laboratory findings of organ crosstalk in AKI and highlight the related molecular mechanisms. Moreover, their crosstalk involves inflammatory and immune responses, hemodynamic change, fluid homeostasis, hormone secretion, nerve reflex regulation, uremic toxin, and oxidative stress. Our review provides important clues for the intervention for AKI and investigates important therapeutic potential from a new perspective.
Funder
National Key R&D Program of China
National Natural Science Foundation of China
Outstanding Youths Development Scheme of Nanfang Hospital, Southern Medical University
Presidential Foundation of Nanfang Hospital
Guangdong Provincial Clinical Research Center for Kidney Disease
Guangdong Basic and Applied Basic Research Foundation
Cited by
13 articles.
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