Abstract
In the search for new carriers capable of transporting toxic drugs to a target, particular attention has been devoted to supramolecular systems with a ribbon-like micellar structure of which Congo red is an example. A special promise of the possible use of such systems for directing drugs to a target emerges from their particular affinity to immune complexes and as an independent property, binding many organic compounds including drugs by intercalation. Serum albumin also appeared able to bind micellar particles of such systems. It may protect them against dilution in transport. The mathematical tool, which relies on analysis of the distribution of polarity and hydrophobicity in protein molecules (fuzzy oil drop model), has been used to find the location of binding area in albumin as well as anchorage site for Congo red in heated IgG light chain used as a model presenting immunoglobulin-like structures. Results confirm the suggested formerly binding site of Congo red in V domain of IgG light chain and indicated the cleft between pseudo-symmetric domains of albumin as the area of attachment for the dye.
Funder
National Science Centre, Poland
Subject
Molecular Biology,Biochemistry
Reference26 articles.
1. Supramolecular Systems as Protein Ligands;Rybarska,2017
2. Supramolecular Congo Red as Specific Ligand of Antibodies Engaged in Immune Complex;Jagusiak,2017
3. All about Albumin-Biochemistry, Genetics and Medical Applications;Peters,1996
4. Structural basis of albumin-thyroxine interactions and familial dysalbuminemic hyperthyroxinemia
5. Three quaternary structures for a single protein.
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献