Wound Modulations in Glaucoma Surgery: A Systematic Review-Reference-Cited by-同舟云学术

Wound Modulations in Glaucoma Surgery: A Systematic Review

Published:2024-04-30 Issue:5 Volume:11 Page:446
ISSN:2306-5354
Container-title:Bioengineering
language:en
Short-container-title:Bioengineering

Author:

Dave Bhoomi¹²,Patel Monica¹,Suresh Sruthi¹,Ginjupalli Mahija¹,Surya Arvind¹^ORCID,Albdour Mohannad³,Kooner Karanjit S.¹⁴^ORCID

Affiliation:

1. Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA

2. Drexel University College of Medicine, Philadelphia, PA 19129, USA

3. Department of Ophthalmology, King Hussein Medical Center Royal Medical Services, Amman 11180, Jordan

4. Department of Ophthalmology, Veteran Affairs North Texas Health Care System Medical Center, Dallas, TX 75216, USA

Abstract

Excessive fibrosis and resultant poor control of intraocular pressure (IOP) reduce the efficacy of glaucoma surgeries. Historically, corticosteroids and anti-fibrotic agents, such as mitomycin C (MMC) and 5-fluorouracil (5-FU), have been used to mitigate post-surgical fibrosis, but these have unpredictable outcomes. Therefore, there is a need to develop novel treatments which provide increased effectiveness and specificity. This review aims to provide insight into the pathophysiology behind wound healing in glaucoma surgery, as well as the current and promising future wound healing agents that are less toxic and may provide better IOP control.

Funder

Research to Prevent Blindness, New York, NY, USA

Publisher

MDPI AG

Link

https://www.mdpi.com/2306-5354/11/5/446/pdf

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