Data-Driven Insights into Labor Progression with Gaussian Processes

Author:

Zhoroev Tilekbek12ORCID,Hamilton Emily F.13ORCID,Warrick Philip A.14ORCID

Affiliation:

1. Medical Research and Development, PeriGen Inc., Cary, NC 27518, USA

2. Department of Applied Mathematics, North Carolina State University, Raleigh, NC 27606, USA

3. Department of Obstetrics and Gynecology, McGill University, Montreal, QC H3A 0G4, Canada

4. Department of Biomedical Engineering, McGill University, Montreal, QC H3A 0G4, Canada

Abstract

Clinicians routinely perform pelvic examinations to assess the progress of labor. Clinical guidelines to interpret these examinations, using time-based models of cervical dilation, are not always followed and have not contributed to reducing cesarean-section rates. We present a novel Gaussian process model of labor progress, suitable for real-time use, that predicts cervical dilation and fetal station based on clinically relevant predictors available from the pelvic exam and cardiotocography. We show that the model is more accurate than a statistical approach using a mixed-effects model. In addition, it provides confidence estimates on the prediction, calibrated to the specific delivery. Finally, we show that predicting both dilation and station with a single Gaussian process model is more accurate than two separate models with single predictions.

Funder

PeriGen, Inc.

Publisher

MDPI AG

Subject

Bioengineering

Reference28 articles.

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2. American College of Obstetricians and Gynecologists (College), Society for Maternal-Fetal Medicine, Caughey, A.B., Cahill, A.G., Guise, J.M., and Rouse, D.J. (2014). Safe prevention of the primary cesarean delivery. Am. J. Obstet. Gynecol., 210, 179–193.

3. World Health Organization (2023, December 10). WHO Labour Care Guide: User’s Manual. Geneva, 2023. Licence: CC BY-NC-SA 3.0 IGO. Available online: https://www.who.int/publications/i/item/9789240017566.

4. Computer analysis of labour progression;Friedman;J. Obstet. Gynaecol. Br. Commonw.,1969

5. Statistical aspects of modeling the labor curve;Zhang;Am. J. Obstet. Gynecol.,2015

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