Broadening the Horizons of RNA Delivery Strategies in Cancer Therapy

Author:

Wu Shuaiying,Liu Chao,Bai Shuang,Lu Zhixiang,Liu GangORCID

Abstract

RNA-based therapy is a promising and innovative strategy for cancer treatment. However, poor stability, immunogenicity, low cellular uptake rate, and difficulty in endosomal escape are considered the major obstacles in the cancer therapy process, severely limiting the development of clinical translation and application. For efficient and safe transport of RNA into cancer cells, it usually needs to be packaged in appropriate carriers so that it can be taken up by the target cells and then be released to the specific location to perform its function. In this review, we will focus on up-to-date insights of the RNA-based delivery carrier and comprehensively describe its application in cancer therapy. We briefly discuss delivery obstacles in RNA-mediated cancer therapy and summarize the advantages and disadvantages of different carriers (cationic polymers, inorganic nanoparticles, lipids, etc.). In addition, we further summarize and discuss the current RNA therapeutic strategies approved for clinical use. A comprehensive overview of various carriers and emerging delivery strategies for RNA delivery, as well as the current status of clinical applications and practice of RNA medicines are classified and integrated to inspire fresh ideas and breakthroughs.

Publisher

MDPI AG

Subject

Bioengineering

Cited by 4 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. RNA therapies for CNS diseases;Advanced Drug Delivery Reviews;2024-05

2. Advances in RNA therapeutics for modulation of ‘undruggable’ targets;Progress in Molecular Biology and Translational Science;2024

3. Bioengineered nanotechnology for nucleic acid delivery;Journal of Controlled Release;2023-12

4. RNA Vaccines: Yeast as a Novel Antigen Vehicle;Vaccines;2023-08-07

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