Affiliation:
1. Regenerative Medicine Group, Department of Health Science and Technology, Aalborg University, DK-9260 Gistrup, Denmark
2. CTS Ferroperm Piezoceramics, DK-3490 Kvistgaard, Denmark
Abstract
Excessive skin scarring affects over 100 million patients worldwide, with effects ranging from cosmetic to systemic problems, and an effective treatment is yet to be found. Ultrasound-based therapies have been used to treat a variety of skin disorders, but the exact mechanisms behind the observed effects are still unclear. The aim of this work was to demonstrate the potential of ultrasound for the treatment of abnormal scarring by developing a multi-well device based on printable piezoelectric material (PiezoPaint™). First, compatibility with cell cultures was evaluated using measurements of heat shock response and cell viability. Second, the multi-well device was used to treat human fibroblasts with ultrasound and quantify their proliferation, focal adhesions, and extracellular matrix (ECM) production. Ultrasound caused a significant reduction in fibroblast growth and ECM deposition without changes in cell viability or adhesion. The data suggest that these effects were mediated by nonthermal mechanisms. Interestingly, the overall results suggest that ultrasound treatment would a be beneficial therapy for scar reduction. In addition, it is expected that this device will be a useful tool for mapping the effects of ultrasound treatment on cultured cells.
Reference49 articles.
1. Hypertrophic Scarring and Keloids: Pathomechanisms and Current and Emerging Treatment Strategies;Gauglitz;Mol. Med.,2010
2. Skin scarring;Bayat;BMJ,2003
3. Fibroblasts in Scar Formation: Biology and Clinical Translation;Qian;Oxid. Med. Cell. Longev.,2022
4. Silicone sheets and new gels to treat hypertrophic scars and keloids: A short review;Gold;Dermatol. Ther.,2020
5. Update on hypertrophic scar treatment;Rabello;Clinics,2014
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献