MRI Liver Imaging Integrated with Texture Analysis in Native Liver Survivor Patients with Biliary Atresia after Kasai Portoenterostomy: Correlation with Medical Outcome after Surgical Treatment

Author:

Caruso Martina1ORCID,Stanzione Arnaldo1ORCID,Ricciardi Carlo23ORCID,Di Dato Fabiola4,Pisani Noemi1ORCID,Delli Paoli Gregorio1ORCID,De Giorgi Marco1,Liuzzi Raffaele5,Mollica Carmine5,Romeo Valeria1ORCID,Iorio Raffaele4,Cesarelli Mario23,Brunetti Arturo1,Maurea Simone1ORCID

Affiliation:

1. Department of Advanced Biomedical Sciences, University of Naples “Federico II”, 80131 Naples, Italy

2. Department of Electrical Engineering and Information Technology, University of Naples “Federico II”, 80125 Naples, Italy

3. Bioengineering Unit, Institute of Care and Scientific Research Maugeri, 82037 Telese Terme, Italy

4. Department of Translational Medical Sciences, University of Naples “Federico II”, 80131 Naples, Italy

5. Institute of Bio-Structures and Bio-Imaging of the National Research Council (CNR), Via Tommaso De Amicis, 80145 Naples, Italy

Abstract

Kasai portoenterostomy (KP) plays a crucial role in the treatment of biliary atresia (BA). The aim is to correlate MRI quantitative findings of native liver survivor BA patients after KP with a medical outcome. Thirty patients were classified as having ideal medical outcomes (Group 1; n = 11) if laboratory parameter values were in the normal range and there was no evidence of chronic liver disease complications; otherwise, they were classified as having nonideal medical outcomes (Group 2; n = 19). Liver and spleen volumes, portal vein diameter, liver mean, and maximum and minimum ADC values were measured; similarly, ADC and T2-weighted textural parameters were obtained using ROI analysis. The liver volume was significantly (p = 0.007) lower in Group 2 than in Group 1 (954.88 ± 218.31 cm3 vs. 1140.94 ± 134.62 cm3); conversely, the spleen volume was significantly (p < 0.001) higher (555.49 ± 263.92 cm3 vs. 231.83 ± 70.97 cm3). No differences were found in the portal vein diameter, liver ADC values, or ADC and T2-weighted textural parameters. In conclusion, significant quantitative morpho-volumetric liver and spleen abnormalities occurred in BA patients with nonideal medical outcomes after KP, but no significant microstructural liver abnormalities detectable by ADC values and ADC and T2-weighted textural parameters were found between the groups.

Publisher

MDPI AG

Subject

Bioengineering

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