Real-Time Monitoring Using Multiplexed Multi-Electrode Bioelectrical Impedance Spectroscopy for the Stratification of Vascularized Composite Allografts: A Perspective on Predictive Analytics

Author:

Aggas John R.12ORCID,Abasi Sara13,Ton Carolyn45,Salehi Sara45,Liu Renee45,Brandacher Gerald56ORCID,Grayson Warren L.45789,Guiseppi-Elie Anthony11011ORCID

Affiliation:

1. Bioelectronics, Biosensors and Biochips (C3B®), Department of Biomedical Engineering, Department of Electrical and Computer Engineering, Texas A&M University, College Station, TX 77843, USA

2. Test Development, Roche Diagnostics, 9115 Hague Road, Indianapolis, IN 46256, USA

3. Media and Metabolism, Wildtype, Inc., 2325 3rd St., San Francisco, CA 94107, USA

4. Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21231, USA

5. Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, MD 21231, USA

6. Department of Plastic & Reconstructive Surgery, Johns Hopkins University, Baltimore, MD 21218, USA

7. Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA

8. Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD 21218, USA

9. Institute for Nanobiotechnology, Johns Hopkins University, Baltimore, MD 21218, USA

10. Department of Cardiovascular Sciences, Houston Methodist Institute for Academic Medicine and Houston Methodist Research Institute, 6670 Bertner Ave., Houston, TX 77030, USA

11. ABTECH Scientific, Inc., Biotechnology Research Park, 800 East Leigh Street, Richmond, VA 23219, USA

Abstract

Vascularized composite allotransplantation addresses injuries to complex anatomical structures such as the face, hand, and abdominal wall. Prolonged static cold storage of vascularized composite allografts (VCA) incurs damage and imposes transportation limits to their viability and availability. Tissue ischemia, the major clinical indication, is strongly correlated with negative transplantation outcomes. Machine perfusion and normothermia can extend preservation times. This perspective introduces multiplexed multi-electrode bioimpedance spectroscopy (MMBIS), an established bioanalytical method to quantify the interaction of the electrical current with tissue components, capable of measuring tissue edema, as a quantitative, noninvasive, real-time, continuous monitoring technique to provide crucially needed assessment of graft preservation efficacy and viability. MMBIS must be developed, and appropriate models explored to address the highly complex multi-tissue structures and time-temperature changes of VCA. Combined with artificial intelligence (AI), MMBIS can serve to stratify allografts for improvement in transplantation outcomes.

Funder

Office of the Assistant Secretary of Defense for Health Affairs

Department of Defense

Texas Engineering Experiment Station

Publisher

MDPI AG

Subject

Bioengineering

Reference89 articles.

1. Farhadieh, R.D., Bulstrode, N.W., Mehrara, B.J., and Cugno, S. (2022). Plastic Surgery—Principles and Practice, Elsevier.

2. Novel immunological and clinical insights in vascularized composite allotransplantation;Kollar;Curr. Opin. Organ Transplant.,2019

3. Outcomes after hand and upper extremity transplantation;Shores;J. Mater. Sci. Mater. Med.,2017

4. The Evolving Clinical Presentation of Acute Rejection in Facial Transplantation;Haug;JAMA Facial Plast. Surg.,2019

5. Vascularized Composite Allograft Transplantation in the United States: Current State of the Field and Future Challenges;Wainright;Transplantation,2022

Cited by 3 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3