Affiliation:
1. Department of Biology, College of Science and Humanities in Al-Kharj, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia
2. Department of Botany & Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia
3. Department of Physics, School of Technology and Sciences, Sao Paulo State University, (Unesp), Sao Paulo 19060-900, Brazil
Abstract
This study aimed to enhance the anticancer and antibacterial properties of Pistacia atlantica through a new parenteral formulation. The innovative approach involved loading P. atlantica fruit extract onto a novel Pluronic vesicular nano platform (Nio), analyzed using various techniques like GC-Mass, SEM, DLS, and UV-vis. The results revealed a stable, spherical Nio/Extract formulation of 103 ± 4.1 nm, possessing a high zeta potential of −30 ± 2.3 mV, with an impressive encapsulation efficiency of nearly 90 ± 3.5%. This formulation exhibited heightened cytotoxicity against BT-20 and MCF-10 cell lines compared to the extract alone, indicating its potential as a drug carrier with prolonged release characteristics. Additionally, the Nio/Extract demonstrated superior antibacterial effects against Pseudomonas aeruginosa, Staphylococcus epidermidis, and Candida albicans compared to the free extract, showcasing MIC values of 211, 147, and 187 ug/mL, respectively, versus 880, 920, and 960 ug/mL for the pathogens. These findings highlight the potential of niosomal nano-carriers housing P. atlantica extract as a viable therapeutic strategy for combating both malignancies and microbial infections.
Funder
Deputyship for Research & Innovation, Ministry of Education in Saudi Arabia
Subject
Microbiology (medical),Molecular Biology,Microbiology
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