3L, Three-Lactobacilli on Recovering of Microbiome and Immune-Damage by Cyclophosphamide Chemotherapy—A Pilot Experiment in Rats

Author:

Yue Shousong1,Zhang Zhenzhong2,Bian Fei1ORCID,Zhang Yan1,Chen Gao1,Zhu Youfeng1,Li Jun2,Picimbon Jean-François134

Affiliation:

1. Institute of Biotechnology Research, Shandong Academy of Agricultural Sciences, Jinan 250100, China

2. School of Pharmaceutical Sciences & Institute of Materia Medica, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250117, China

3. School of Bioengineering, Qilu University of Technology, Jinan 250353, China

4. Science and Technology Service Platform of Shandong Academy of Sciences, Shandong Academy of Sciences Foreign Students Pioneer Park, Shandong Academy of Sciences, Jinan 250103, China

Abstract

We deal with various strains of Lactobacillus that can maintain the intestinal microbiome of rats treated with cyclophosphamide, an anticancer agent (chemotherapy). We use MiSeq and various types of statistical tests to prove that cyclophosphamide in rats alters the intestinal microbiome, favoring the growth of various fungi that are extremely harmful to intestinal metabolism. On the contrary, when Lactobacillus 3L is administered together with cyclophosphamide, we prove that the microbiome is preserved by having a much better intestinal metabolism.

Funder

Shandong Province Overseas High-Level Talents Program

Key Research and Development of Shandong Province

Agricultural Science and Technology Innovation Engineering Program of Shandong Academy of Agricultural Sciences

Academic Promotion Program of Shandong First Medical University

Publisher

MDPI AG

Subject

Microbiology (medical),Molecular Biology,Microbiology

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3