Affiliation:
1. Department of Agricultural Sciences, Biotechnology and Food Science, Cyprus University of Technology, Lemesos 3603, Cyprus
Abstract
Plants possess endless structural and chemical diversity, which is peerless with any synthetic library of small biomolecules, inspiring novel drug discovery. Plants are widely applied to encounter global health challenges such as antimicrobial resistance and diabetes. The objective of this work was to evaluate the antibacterial and antidiabetic potency of native plants grown in Cyprus. All plants were sequentially extracted with solvents of increasing polarity, namely hexane, acetone, methanol, and water. First, the phenolic and flavonoid contents of the extracts were assessed. Afterwards, the bacteriostatic and bactericidal potency of plant extracts were tested against a panel of six bacteria using the broth microdilution method, whereas the inhibitory effects on alpha-glucosidase and alpha-amylase enzymes were also determined with the employment of microplate assays. The results highlighted the superiority of Sarcopoterium spinosum as a potential enzyme inhibitor, while a knowledge base was also acquired for the inhibitory potential of all plants. Daucus carota, Ferula communis, and Tordylium.aegyptiacum displayed additionally outstanding bacteriostatic and bactericidal effects on Gram-positive bacteria at concentrations of 250 µg mL−1 and 500 µg mL−1. Overall, the present study describes the antibacterial and inhibitory activity against carbohydrate digestive enzymes of native plants grown in Cyprus delivering the first reports for many plant species.
Funder
Research & Innovation Foundation
Cyprus University of Technology (CUT) Open Access Author Fund
Reference48 articles.
1. Natural Products in Drug Discovery: Advances and Opportunities;Atanasov;Nat. Rev. Drug Discov.,2021
2. Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019;Newman;J. Nat. Prod.,2020
3. Zhu, W., Huang, W., Xu, Z., Cao, M., Hu, Q., Pan, C., Guo, M., Wei, J.F., and Yuan, H. (2019). Analysis of Patents Issued in China for Antihyperglycemic Therapies for Type 2 Diabetes Mellitus. Front. Pharmacol., 10.
4. Natural Products for Human Health: An Historical Overview of the Drug Discovery Approaches;Bernardini;Nat. Prod. Res.,2018
5. Marketing Trends & Future Prospects of Herbal Medicine in the Treatment of Various Diseases;Gunjan;World J. Pharm. Res.,2015
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献