Effect of Lactoferrin on Clinical Outcomes of Hospitalized Patients with COVID-19: The LAC Randomized Clinical Trial-Reference-Cited by-同舟云学术

Effect of Lactoferrin on Clinical Outcomes of Hospitalized Patients with COVID-19: The LAC Randomized Clinical Trial

Published:2023-03-04 Issue:5 Volume:15 Page:1285
ISSN:2072-6643
Container-title:Nutrients
language:en
Short-container-title:Nutrients

Author:

Matino Erica¹²³,Tavella Elena⁴⁵^ORCID,Rizzi Manuela⁶^ORCID,Avanzi Gian Carlo¹³,Azzolina Danila¹^ORCID,Battaglia Antonio⁷,Becco Paolo⁸,Bellan Mattia¹³⁹^ORCID,Bertinieri Giovanni¹⁰,Bertoletti Massimo¹¹,Casciaro Giuseppe Francesco¹²³,Castello Luigi Mario¹¹²^ORCID,Colageo Umberto¹³,Colangelo Donato⁶^ORCID,Comolli Davide¹,Costanzo Martina¹²³,Croce Alessandro¹²³,D’Onghia Davide¹^ORCID,Della Corte Francesco¹¹⁴^ORCID,De Mitri Luigi¹⁵,Dodaro Valentina⁵,Givone Filippo¹¹,Gravina Alessia¹⁶,Grillenzoni Luca¹⁶,Gusmaroli Graziano¹⁷,Landi Raffaella¹²³,Lingua Anna¹⁸,Manzoni Roberto⁷,Marinoni Vito¹⁹,Masturzo Bianca²⁰^ORCID,Minisini Rosalba¹^ORCID,Morello Marina¹⁶,Nelva Anna¹⁵,Ortone Elena¹⁹,Paolella Rita¹⁶,Patti Giuseppe¹²¹^ORCID,Pedrinelli Anita¹²³,Pirisi Mario¹²³⁹,Ravizzi Lidia¹¹,Rizzi Eleonora¹²³^ORCID,Sola Daniele¹²^ORCID,Sola Mariolina¹⁶,Tonello Nadir¹⁶,Tonello Stelvio¹⁹^ORCID,Topazzo Gigliola¹⁵,Tua Aldo¹⁶,Valenti Piera²²,Vaschetto Rosanna¹¹⁴^ORCID,Vassia Veronica¹²³^ORCID,Zecca Erika¹²³^ORCID,Zublena Nicoletta²³,Manzoni Paolo⁴⁵^ORCID,Sainaghi Pier Paolo¹²³⁹^ORCID

Affiliation:

1. Department of Translational Medicine, Università del Piemonte Orientale (UPO), 28100 Novara, Italy

2. Department of Internal Medicine and COVID-19 Unit, Azienda Ospedaliero-Universitaria (AOU) “Maggiore della Carità”, 28100 Novara, Italy

3. Division of Emergency Medicine and COVID-19 Sub-Intensive Unit, Azienda Ospedaliero-Universitaria (AOU) “Maggiore della Carità”, 28100 Novara, Italy

4. Department of Maternal-Infant Medicine, Ospedale degli Infermi, 13875 Ponderano, Italy

5. Internal Medicine, Department of Medical Sciences, Azienda Ospedaliero-Universitaria (AOU) Città della Salute e della Scienza, University of Turin School of Medicine, 10126 Turin, Italy

6. Department of Health Sciences, Università del Piemonte Orientale (UPO), 28100 Novara, Italy

7. Division of Dermatology, Ospedale degli Infermi, 13875 Ponderano, Italy

8. Division of Oncology, Ospedale degli Infermi, 13875 Ponderano, Italy

9. CAAD, Center for Autoimmune and Allergic Diseases, Università del Piemonte Orientale (UPO), 28100 Novara, Italy

10. Division of Internal Medicine, Ospedale degli Infermi, 13875 Ponderano, Italy

11. Division of Pneumology, Ospedale degli Infermi, 13875 Ponderano, Italy

12. Division of Internal Medicine, Azienda Ospedaliera “SS. Antonio e Biagio e Cesare Arrigo”, 15121 Alessandria, Italy

13. Intensive Care Unit, Ospedale degli Infermi, 13875 Ponderano, Italy

14. Department of Anesthesia and Intensive Care Medicine, AOU “Maggiore della Carità”, 28100 Novara, Italy

15. Division of Diabetology and Endocrinology, Ospedale degli Infermi, 13875 Ponderano, Italy

16. Division of Emergency Medicine, Ospedale degli Infermi, 13875 Ponderano, Italy

17. Division of Neurology, Ospedale degli Infermi, 13875 Ponderano, Italy

18. Division of Infectious Disease, Ospedale degli Infermi, 13875 Ponderano, Italy

19. Division of Geriatric Care, Ospedale degli Infermi, 13875 Ponderano, Italy

20. Division of Obstetrics and Gynecology, Ospedale degli Infermi, 13875 Ponderano, Italy

21. Medical Department, Division of Cardiology, AOU “Maggiore della Carità”, 28100 Novara, Italy

22. Department of Public Health and Infectious Diseases, University of Rome, La Sapienza, 00185 Rome, Italy

23. Division of Palliative Care, Ospedale degli Infermi, 13875 Ponderano, Italy

Abstract

As lactoferrin is a nutritional supplement with proven antiviral and immunomodulatory abilities, it may be used to improve the clinical course of COVID-19. The clinical efficacy and safety of bovine lactoferrin were evaluated in the LAC randomized double-blind placebo-controlled trial. A total of 218 hospitalized adult patients with moderate-to-severe COVID-19 were randomized to receive 800 mg/die oral bovine lactoferrin (n = 113) or placebo (n = 105), both given in combination with standard COVID-19 therapy. No differences in lactoferrin vs. placebo were observed in the primary outcomes: the proportion of death or intensive care unit admission (risk ratio of 1.06 (95% CI 0.63–1.79)) or proportion of discharge or National Early Warning Score 2 (NEWS2) ≤ 2 within 14 days from enrollment (RR of 0.85 (95% CI 0.70–1.04)). Lactoferrin showed an excellent safety and tolerability profile. Even though bovine lactoferrin is safe and tolerable, our results do not support its use in hospitalized patients with moderate-to-severe COVID-19.

Publisher

MDPI AG

Subject

Food Science,Nutrition and Dietetics

Link

https://www.mdpi.com/2072-6643/15/5/1285/pdf

Reference84 articles.

1. SARS-CoV-2 pathogenesis;Lamers;Nat. Rev. Microbiol.,2022

2. Mechanistic Insights into the Immune Pathophysiology of COVID-19; An In-Depth Review;Shafqat;Front. Immunol.,2022

3. Characteristics of SARS-CoV-2 and COVID-19;Hu;Nat. Rev. Microbiol.,2021

4. The COVID-19 puzzle: Deciphering pathophysiology and phenotypes of a new disease entity;Osuchowski;Lancet Respir. Med.,2021

5. Cytokine signature and COVID-19 prediction models in the two waves of pandemics;Cabaro;Sci. Rep.,2021

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