Effect of the Combination of Synthetic Anthelmintics with Carvacryl Acetate in Emulsions with and without a Sodium Alginate Matrix on Haemonchus contortus-Reference-Cited by-同舟云学术

Effect of the Combination of Synthetic Anthelmintics with Carvacryl Acetate in Emulsions with and without a Sodium Alginate Matrix on Haemonchus contortus

Published:2024-03-26 Issue:7 Volume:14 Page:1007
ISSN:2076-2615
Container-title:Animals
language:en
Short-container-title:Animals

Author:

Ximenes Livia Furtado¹,Pinheiro Henety Nascimento²^ORCID,Filho José Vilemar de Araújo¹^ORCID,André Weibson Paz Pinheiro¹^ORCID,Abreu Flávia Oliveira Monteiro da Silva²^ORCID,Cardial Mayrla Rocha Lima²,Castelo-Branco Debora de Souza Colares Maia³^ORCID,Melo Ana Carolina Fonseca Lindoso³^ORCID,Lopes Francisco Flávio da Silva⁴,de Morais Selene Maia⁴^ORCID,de Oliveira Lorena Mayana Beserra¹^ORCID,Bevilaqua Claudia Maria Leal¹^ORCID

Affiliation:

1. Laboratório de Doenças Parasitárias, Programa de Pós-Graduação em Ciências Veterinárias, Faculdade de Veterinária, Universidade Estadual do Ceará, Fortaleza 60714-903, Ceará, Brazil

2. Laboratório de Química Analítica e Ambiental, Programa de Pós-Graduação em Ciências Naturais, Universidade Estadual do Ceará, Fortaleza 60714-903, Ceará, Brazil

3. Departamento de Patologia e Medicina Legal, Faculdade de Medicina, Universidade Federal do Ceará, Fortaleza 60714-903, Ceará, Brazil

4. Laboratório de Química de Produtos Naturais, Programa de Pós-Graduação em Ciências Veterinárias, Faculdade de Veterinária, Universidade Estadual do Ceará, Fortaleza 60714-903, Ceará, Brazil

Abstract

The present study aimed to evaluate the effect of nanoemulsions using combined synthetic anthelmintics, thiabendazole (TBZ), levamisole (LEV), and ivermectin (IVM), with carvacryl acetate (CA) against Haemonchus contortus, and also tested the presence and absence of alginate (ALG). The anthelmintic effect of the CA/TBZ nanoemulsion was evaluated in the egg hatch test (EHT). The effects of CA/IVM and CA/LEV nanoemulsions were evaluated in the larval development test (LDT). The emulsions CA/TBZ/ALG and CA/TBZ showed a multimodal profile, with most particles on the nanometric scale. The encapsulation efficiency in CA/TBZ/ALG was 80.25%, and that in CA/LEV/ALG was 89.73%. In the EHT, CA/TBZ and CA/TBZ/ALG showed mean combination indices (CIs) of 0.55 and 0.36, respectively, demonstrating synergism in both. In LDT, CA/IVM had an average CI of 0.75, and CA/LEV and CA/LEV/ALG showed CI values of 0.4 and 0.93, respectively. It was concluded that CA/TBZ showed a synergistic interaction, and CA/TBZ/ALG showed an enhanced effect. In addition, the matrix brought stability to the product, encouraging its improvement to obtain higher efficacy.

Funder

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Fundação Cearense de Apoio ao Desenvolvimento Científico e Tecnológico

Publisher

MDPI AG

Link

https://www.mdpi.com/2076-2615/14/7/1007/pdf

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