Affiliation:
1. School of Public Health, Center for Global Health, Nanjing Medical University, Nanjing 211100, China
2. School of Materials and Chemistry, University of Shanghai for Science and Technology, No. 516 Jungong Road, Shanghai 200093, China
Abstract
Hemostatic powder, which can absorb large amounts of water and tends to produce repeated hydration with tissue, has been clinically proven as an ideal engineering material for treating wounds and tissues. We herein designed a polypeptide-based hemostatic powder. A water-soluble polypeptide, γ-polyglutamic acid (γ-PGA), was mixed with the polyethyleneimine (PEI), N-hydroxysuccinimide, and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide. The solution of these polymers was lyophilized to harvest the γ-PGA/PEI powder (PP hemostatic powder). When deposited on a bleeding wound, the PP hemostatic powder can quickly absorb a large amount of blood and interstitial fluid, concentrate coagulation factors, coagulate blood cells, and eventually form a stable mechanical hydrogel. The wound bleeding time of the PP hemostatic powder group was 1.8 ± 0.4 min, significantly lower than that of the commercial chitosan hemostatic powder group (2.8 ± 0.4 min). The PP hemostatic powder was endowed with antioxidant capacity by introducing protocatechuic aldehyde, which can effectively inhibit inflammation and promote wound healing. Therefore, via preparation through a facile lyophilization method, the PP hemostatic powder is expected to find a wide application prospect as a qualified hemostatic powder.
Reference37 articles.
1. Micro-Gel Ensembles for Accelerated Healing of Chronic Wound via pH Regulation;Cui;Adv. Sci.,2022
2. Nie, L., Wei, Q., Sun, M., Ding, P., Wang, L., Sun, Y., Ding, X., Okoro, O.V., Jiang, G., and Shavandi, A. (2023). Injectable, self-healing, transparent, and antibacterial hydrogels based on chitosan and dextran for wound dressings. Int. J. Biol. Macromol., 233.
3. Aerogelation of Polymer-Coated Photoluminescent, Plasmonic, and Magnetic Nanoparticles for Biosensing Applications;Altenschmidt;ACS Appl. Nano Mater.,2021
4. Interactions between two-dimensional nanoclay and blood cells in hemostasis;Long;Mater. Sci. Eng. C,2019
5. An Antifouling and Antimicrobial Zwitterionic Nanocomposite Hydrogel Dressing for Enhanced Wound Healing;Dai;ACS Biomater. Sci. Eng.,2021
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