Biological Macromolecule-Based Scaffolds for Urethra Reconstruction-Reference-Cited by-全球学者库

Biological Macromolecule-Based Scaffolds for Urethra Reconstruction

Published:2023-07-26 Issue:8 Volume:13 Page:1167
ISSN:2218-273X
Container-title:Biomolecules
language:en
Short-container-title:Biomolecules

Author:

Farzamfar Saeed¹,Richer Megan¹,Rahmani Mahya²^ORCID,Naji Mohammad³,Aleahmad Mehdi⁴,Chabaud Stéphane¹^ORCID,Bolduc Stéphane¹⁵^ORCID

Affiliation:

1. Centre de Recherche en Organogénèse Expérimentale/LOEX, Regenerative Medicine Division, CHU de Québec-Université Laval Research Center, Quebec, QC G1V 4G2, Canada

2. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran 1983963113, Iran

3. Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran 1983963113, Iran

4. Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran 1417613151, Iran

5. Department of Surgery, Faculty of Medicine, Laval University, Quebec, QC G1V 0A6, Canada

Abstract

Urethral reconstruction strategies are limited with many associated drawbacks. In this context, the main challenge is the unavailability of a suitable tissue that can endure urine exposure. However, most of the used tissues in clinical practices are non-specialized grafts that finally fail to prevent urine leakage. Tissue engineering has offered novel solutions to address this dilemma. In this technology, scaffolding biomaterials characteristics are of prime importance. Biological macromolecules are naturally derived polymers that have been extensively studied for various tissue engineering applications. This review discusses the recent advances, applications, and challenges of biological macromolecule-based scaffolds in urethral reconstruction.

Funder

Fondation du CHU de Quebec

Publisher

MDPI AG

Subject

Molecular Biology,Biochemistry

Link

https://www.mdpi.com/2218-273X/13/8/1167/pdf

Reference193 articles.

1. Tissue engineering of the urethra: Where are we in 2019?;Chapple;World J. Urol.,2020

2. Current state of urethral tissue engineering;Mangir;Curr. Opin. Urol.,2019

3. Reconstructive urology and tissue engineering: Converging developmental paths;Adamowicz;J. Tissue Eng. Regen. Med.,2019

4. Xuan, Z., Zachar, V., and Pennisi, C.P. (2022). Sources, Selection, and Microenvironmental Preconditioning of Cells for Urethral Tissue Engineering. Int. J. Mol. Sci., 23.

5. Casarin, M., Morlacco, A., and Dal Moro, F. (2022). Tissue engineering and regenerative medicine in pediatric urology: Urethral and urinary bladder reconstruction. Int. J. Mol. Sci., 23.