Asymmetric Friedel–Crafts Alkylation of Indoles Catalyzed by Chiral Aziridine-Phosphines

Author:

Buchcic Aleksandra,Zawisza AnnaORCID,Leśniak Stanisław,Rachwalski MichałORCID

Abstract

Over the course of the present studies, a series of optically pure phosphines functionalized by chiral aziridines was synthesized in reasonable/good chemical yields. Their catalytic activity was checked in the enantioselective Friedel–Crafts alkylation of indoles by β-nitrostyrene in the presence of a copper(I) trifluoromethanesulfonate benzene complex. The corresponding Friedel–Crafts products were achieved efficiently in terms of chemical yield and enantioselectivity (up to 85% in some cases).

Funder

Narodowe Centrum Nauki

Publisher

MDPI AG

Subject

Physical and Theoretical Chemistry,Catalysis

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