Abstract
A general procedure for the tandem arylation reaction of arylbromide with heteroaryl compounds was developed by using Pd(PPh3)2Cl2/(±)-BINAP (1,1′-Binaphthalene-2,2′-diylbis (diphenylphosphane)) as catalytic system. Both sulphur- and oxygen-containing heterocycles were also employed as an efficient reagent for arylation, which gave moderate to excellent yields with moderate to good regioselectivities (5:1 to > 20:1 ir (isomer ratio)). Except for dihydrobenzofurans, indolines and indolinones, this type of tandem reaction was also expanded to synthesize isochromanes. The synthesized new compounds were well characterized through different spectroscopic techniques, such as 1H and 13C NMR (nuclear magnetic resonance), and mass spectral analysis.
Subject
Physical and Theoretical Chemistry,Catalysis
Reference80 articles.
1. Advances in the biological activities and synthesis of 2-arylbenzofurans;Pang;Chin. J. Org. Chem.,2005
2. Pyrrolidinyl-spirooxindole natural products as inspirations for the development of potential therapeutic agents;Galliford;Angew. Chem. Int. Ed.,2007
3. Research progress for biological activity of benzothiazolone compounds;Liu;Agrochemicals,2012
4. Recent progress on biological activity and synthesis of 2-substituted benzofuran derivatives;Chen;J. Pharm. Pract.,2013
5. Review of oxindole compounds studies;Zhang;Fine Chem. Intermed.,2016
Cited by
4 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献