Abstract
Reactive oxygen species (ROS) can be used as an effective method to treat tumors. Artificial oxidase has received increasing attention as a catalyst for ROS generation in fields ranging from bioinorganic chemistry to pharmaceutical chemistry. In this study, an artificial oxidase based on a binuclear zinc complex and Keggin-type silicotungstate [Zn2(4,4′-bpy)(Phen)2][SiW12O40] (ZSW) (4,4′-bpy = 4,4′-bipyridine; Phen = 1,10-phenanthroline) was synthesized and structurally featured in terms of its X-ray photoelectron spectrum (XPS), bond valence sum (Σs) calculation, IR spectra, and single-crystal X-ray diffraction (SXRD). ZSW is an ionic compound in which the cation is a binuclear zinc complex [Zn2(4,4′-bpy)(Phen)2]4+ and the anion is a α-Keggin-type silicotungstate [SiW12O40]4– cluster. Notably, the Zn ions in the [Zn2(4,4′-bpy)(Phen)2] exist in tri-coordination, which was first obtained in polyoxometalate (POM) chemistry. It was also demonstrated that ZSW is capable of efficiently catalyzing the production of ROS, which, according to the computational calculations, may be due to the synergistic action of zinc complexes and POM building blocks. Furthermore, ZSW exhibited inhibition ability toward ROS-sensitive tumor cells, such as PC12 cells.
Funder
Scientific and Technologial Innovation Programs of Higher Education Institutions in Shanxi
Shanxi Province Science Foundation for Youths
Subject
Physical and Theoretical Chemistry,Catalysis,General Environmental Science
Cited by
3 articles.
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