Inflammatory Response and Activation of Coagulation after COVID-19 Infection

Author:

Teodoro Anna Glória Fonseca1,Rodrigues Wellington Francisco1,Farnesi-de-Assunção Thais Soares1,Borges Anna V. Bernardes e1,Obata Malu Mateus Santos1,Neto José Rodrigues do Carmo1,da Silva Djalma A. Alves1,Andrade-Silva Leonardo E.1ORCID,Desidério Chamberttan S.1ORCID,Costa-Madeira Juliana C.1,Barbosa Rafaela M.1,Cunha Andrezza C. C. Hortolani2,Pereira Loren Q.3,de Vito Fernanda Bernadelli3,Vaz Tanaka Sarah Cristina Sato3,Helmo Fernanda R.1,Lemes Marcela Rezende1,Barbosa Laís M.1,Trevisan Rafael O.1ORCID,Mundim Fabiano V.1,Oliveira-Scussel Ana Carolina M.1ORCID,Junior Paulo Roberto Resende1,Monteiro Ivan B.45,Ferreira Yulsef M.5,Machado Guilherme H.6,Ferreira-Paim Kennio1ORCID,Moraes-Souza Hélio3,de Oliveira Carlo José Freire1ORCID,Rodrigues Júnior Virmondes1ORCID,Silva Marcos Vinicius da1ORCID

Affiliation:

1. Department of Immunology, Microbiology and Parasitology, Federal University of Triângulo Mineiro, Uberaba 38025-350, Brazil

2. Postgraduate Program in Physiological Sciences, Federal University of Triângulo Mineiro, Uberaba 38025-200, Brazil

3. Laboratory of Hematological Research of the Federal University of Triângulo Mineiro and Regional Blood Center of Uberaba—Hemominas Foundation, Uberaba 38025-440, Brazil

4. UNIMED São Domingos Hospital, Uberaba 38025-110, Brazil

5. José Alencar Gomes da Silva Regional Hospital, Uberaba 38060-200, Brazil

6. Mário Palmério University Hospital, Uberaba 38050-501, Brazil

Abstract

SARS-CoV-2 (COVID-19) infection is responsible for causing a disease with a wide spectrum of clinical presentations. Predisposition to thromboembolic disease due to excessive inflammation is also attributed to the disease. The objective of this study was to characterize the clinical and laboratory aspects of hospitalized patients, in addition to studying the pattern of serum cytokines, and associate them with the occurrence of thromboembolic events. Methodology: A retrospective cohort study with 97 COVID-19 patients hospitalized from April to August 2020 in the Triângulo Mineiro macro-region was carried out. A review of medical records was conducted to evaluate the clinical and laboratory aspects and the frequency of thrombosis, as well as the measurement of cytokines, in the groups that presented or did not present a thrombotic event. Results: There were seven confirmed cases of thrombotic occurrence in the cohort. A reduction in the time of prothrombin activity was observed in the group with thrombosis. Further, 27.8% of all patients had thrombocytopenia. In the group that had thrombotic events, the levels of IL1b, IL-10, and IL2 were higher (p < 0.05). Conclusions: In the studied sample, there was an increase in the inflammatory response in patients with thrombotic events, confirmed by the increase in cytokines. Furthermore, in this cohort, a link was observed between the IL-10 percentage and an increased chance of a thrombotic event.

Funder

Federal University of Triângulo Mineiro (UFTM), Fundação de Amparo à Pesquisa do Estado Minas Gerais

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Publisher

MDPI AG

Subject

Virology,Infectious Diseases

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