Deferoxamine-Loaded Chitosan-Based Hydrogel on Bone Implants Showing Enhanced Bond Strength and Pro-Angiogenic Effects-Reference-Cited by-同舟云学术

Deferoxamine-Loaded Chitosan-Based Hydrogel on Bone Implants Showing Enhanced Bond Strength and Pro-Angiogenic Effects

Published:2024-04-22 Issue:4 Volume:15 Page:112
ISSN:2079-4983
Container-title:Journal of Functional Biomaterials
language:en
Short-container-title:JFB

Author:

Liu Huan¹,Li Kai²³^ORCID,Yi Deliang²³,Ding Yi²,Gao Yanfeng¹,Zheng Xuebin²³

Affiliation:

1. School of Materials Science and Engineering, Shanghai University, 99 Shangda Road, Shanghai 200444, China

2. Key Laboratory of Inorganic Coating Materials CAS, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai 200050, China

3. Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, China

Abstract

Angiogenesis is vital for bone fracture healing and plays a significant role in the fate of orthopedic implants. The growth and maintenance of new blood vessels at the fracture site of patients is essential, which promotes the clinical outcome of plasma sprayed Ti (PST) coated orthopedic implants. In order to endow the PST coating with pro-angiogenic effects, deferoxamine-loaded chitosan-based hydrogel was fabricated on the coating surface. Polydopamine-modified chitosan (CS/PDA) hydrogel exhibited enhanced bonding strength to PST coatings as evidenced by scratch test. The deferoxamine-loaded CS/PDA (CS/PDA-DFO) exhibited a sustained drug-release property, and the cumulative concentration of released DFO reached 20.21 μg/mL on day 7. PST-CS/PDA with higher wettability and active group quantity enhanced the viability and adhesion characteristics of human umbilical vein endothelial cells (HUVECs) and upregulated the secretion level of nitric oxide and vascular endothelial growth factor. Moreover, the introduction of DFO in PST-CS/PDA further enhanced the pro-angiogenic effects. Above all, this study offers a novel approach for developing hydrogel coating on orthopedic implants showing enhanced bonding strength and pro-angiogenic effects.

Funder

National Natural Science Foundation of China

Shanghai Rising-Star Program

Science and Technology Commission of Shanghai Municipality

Youth Innovation Promotion Association of the Chinese Academy of Sciences

Publisher

MDPI AG

Link

https://www.mdpi.com/2079-4983/15/4/112/pdf

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