Abstract
Oxidative stress represents one of the main factors driving the pathophysiology of multiple ophthalmic conditions including presbyopia, cataracts, dry eye disease (DED), glaucoma, age-related macular degeneration (AMD) and diabetic retinopathy (DR). Currently, different studies have demonstrated the role of orally administered nutraceuticals in these diseases. For instance, they have demonstrated to improve lens accommodation in presbyopia, reduce protein aggregation in cataracts, ameliorate tear film stability, break up time, and tear production in dry eye, and participate in the avoidance of retinal neuronal damage and a decrease in intraocular pressure in glaucoma, contribute to the delayed progression of AMD, or in the prevention or treatment of neuronal death in diabetic retinopathy. In this review, we summarized the nutraceuticals which have presented a positive impact in ocular disorders, emphasizing the clinical assays. The characteristics of the different types of nutraceuticals are specified along with the nutraceutical concentration used to achieve a therapeutic outcome in ocular diseases.
Subject
Food Science,Nutrition and Dietetics
Reference251 articles.
1. Topical applied nutraceutical antioxidant formulation reduces ocular oxidative stress;Funct. Foods Health Dis.,2017
2. Oral supplementation with a nutraceutical formulation containing omega-3 fatty acids, vitamins, minerals, and antioxidants in a large series of patients with dry eye symptoms: Results of a prospective study;Clin. Interv. Aging,2016
3. Effects of topical fucosyl-lactose, a milk oligosaccharide, on dry eye model: An example of nutraceutical candidate;Front. Pharmacol.,2015
4. Impact of nutraceuticals on glaucoma: A systematic review;Prog. Brain Res.,2020
5. Functional foods and the immune system: A review;Eur. J. Clin. Nutr.,2002
Cited by
14 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献