Resistance Training Increases White Matter Density in Frail Elderly Women-Reference-Cited by-同舟云学术

Resistance Training Increases White Matter Density in Frail Elderly Women

Published:2023-04-04 Issue:7 Volume:12 Page:2684
ISSN:2077-0383
Container-title:Journal of Clinical Medicine
language:en
Short-container-title:JCM

Author:

Bucci Marco¹²³^ORCID,Iozzo Patricia⁴,Merisaari Harri⁵⁶^ORCID,Huovinen Ville¹⁵,Lipponen Heta¹,Räikkönen Katri⁷,Parkkola Riitta⁵^ORCID,Salonen Minna⁸,Sandboge Samuel⁹¹⁰,Eriksson Johan⁸¹¹¹²¹³,Nummenmaa Lauri¹^ORCID,Nuutila Pirjo¹¹⁴^ORCID

Affiliation:

1. Turku PET Centre, University of Turku, 20520 Turku, Finland

2. Theme Inflammation and Aging, Karolinska University Hospital, 141 86 Huddinge, Sweden

3. Department of Neurobiology, Care Sciences and Society, Division of Clinical Geriatrics, Center for Alzheimer Research, Karolinska University, 171 77 Stockholm, Sweden

4. Institute of Clinical Physiology, National Research Council, 56124 Pisa, Italy

5. Department of Radiology, Turku University Hospital, University of Turku, 20014 Turku, Finland

6. Turku Brain and Mind Center, University of Turku, 20014 Turku, Finland

7. Department of Psychology and Logopedics, University of Helsinki, 00014 Helsinki, Finland

8. Folkhälsan Research Centre, 00250 Helsinki, Finland

9. Finnish Institute for Health and Welfare, 00271 Helsinki, Finland

10. Psychology/Welfare Sciences, Faculty of Social Sciences, University of Tampere, 33014 Tampere, Finland

11. Department of General Practice and Primary Health Care, University of Helsinki, Helsinki University Hospital, 00290 Helsinki, Finland

12. Singapore Institute for Clinical Sciences, Agency for Science, Technology, and Research, Singapore 138632, Singapore

13. Department of Obstetrics & Gynaecology and Human Potential Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore

14. Department of Endocrinology, Turku University Hospital, 20520 Turku, Finland

Abstract

We aimed to investigate the effects of maternal obesity on brain structure and metabolism in frail women, and their reversibility in response to exercise. We recruited 37 frail elderly women (20 offspring of lean/normal-weight mothers (OLM) and 17 offspring of obese/overweight mothers (OOM)) and nine non-frail controls to undergo magnetic resonance and diffusion tensor imaging (DTI), positron emission tomography with Fluorine-18-fluorodeoxyglucose (PET), and cognitive function tests (CERAD). Frail women were studied before and after a 4-month resistance training, and controls were studied once. White matter (WM) density (voxel-based morphometry) was higher in OLM than in OOM subjects. Exercise increased WM density in both OLM and OOM in the cerebellum in superior parietal regions in OLM and in cuneal and precuneal regions in OOM. OLM gained more WM density than OOM in response to intervention. No significant results were found from the Freesurfer analysis, nor from PET or DTI images. Exercise has an impact on brain morphology and cognition in elderly frail women.

Funder

DORIAN EU FP7 (DORIAN–Developmental ORIgins of healthy and unhealthy AgeiNg: The role of maternal obesity

Academy of Finland

Finnish Cultural Foundation

South-Western Finland Cultural Foundation

Turku University Foundation

University of Turku

Turku University Hospital

Åbo Academy

Publisher

MDPI AG

Subject