Odds and Predictors of Monozygotic Twinning in a Multicentre Cohort of 25,794 IVF Cycles

Author:

Kadam Nikit1ORCID,Woodhead George2,Kellam Louise2,Campbell Alison2,Jayaprakasan Kanna12ORCID

Affiliation:

1. Derby Fertility Unit, University Hospitals of Deby and Burton, Derby DE22 3NE, UK

2. Care Fertility, Nottingham NG8 6PZ, UK

Abstract

The rate of monozygotic twinning (MZT) has seen a gradual increase in recent years. Numerous parameters involved in ART procedures are blamed for this surge, even though the exact explanation is as yet unknown. Our study’s objectives were to determine the risk variables for monozygotic twinning after ART and to estimate their prevalence. We examined 25,794 IVF cycles for the incidence of monozygotic twinning in this observational analysis. Our study, which was carried out across seven tertiary IVF centres over the course of four years, found an overall MZT rate of 0.37% per embryo transfer procedure and 0.88% of all pregnancies. Monozygotic twinning was more commonly seen in fresh single-embryo transfer (SET) and blastocyst transfer cycles. Larger multicentre studies are needed to explore the potential risk variables.

Publisher

MDPI AG

Subject

General Medicine

Reference15 articles.

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