Calcium, Phosphorus, and Vitamin D Levels in a Series of Cystic Fibrosis Patients: A Cross-Sectional Study
-
Published:2024-02-05
Issue:3
Volume:25
Page:1900
-
ISSN:1422-0067
-
Container-title:International Journal of Molecular Sciences
-
language:en
-
Short-container-title:IJMS
Author:
Escobedo-Monge Marlene Fabiola1ORCID, Marcos-Temprano Marianela2, Parodi-Román Joaquín3, Escobedo-Monge María Antonieta4ORCID, Alonso-Vicente Carmen5, Torres-Hinojal María Carmen1, Marugán-Miguelsanz José Manuel5ORCID
Affiliation:
1. Faculty of Medicine, University of Valladolid, Avenida Ramón y Cajal, 7, 47005 Valladolid, Spain 2. Castilla y León Cystic Fibrosis Unit, University Clinical Hospital of Valladolid, Avenida Ramón y Cajal, 3, 47005 Valladolid, Spain 3. Science Faculty, University of Cadiz, Paseo de Carlos III, 28, 11003 Cádiz, Spain 4. Department of Chemistry, Science Faculty, University of Burgos, Plaza Misael Bañuelos s/n, 09001 Burgos, Spain 5. Department of Pediatrics of the Faculty of Medicine, University of Valladolid; Section of Gastroenterology and Pediatric Nutrition, University Clinical Hospital of Valladolid, Avenida Ramón y Cajal, 7, 47005 Valladolid, Spain
Abstract
Cystic fibrosis (CF) is a monogenic disease with different types of mutations that mainly affect the respiratory-digestive system. Calcium (Ca), phosphorus (P), and vitamin D (Vit-D) are essential nutrients for maintaining adequate growth and development, as well as key components in crucial metabolic pathways. Proper diagnosis, treatment, and response are decisive components of precision medicine. Therefore, we conducted a cross-sectional study to evaluate Ca, P, and Vit-D levels along with health and nutritional indicators, regarding their non-skeletal functions, in a series of CF patients. Anthropometric and clinical evaluation, biochemical analysis, dietary survey, and respiratory and pancreatic status were performed. Even though the results showed that all patients had normal dietary and serum Ca levels, 47% of patients had deficient Vit-D intake, 53% of patients had hypovitaminosis D, 35% had insufficient Vit-D levels, 18% had hypophosphatemia, 76% had elevated alkaline phosphate levels, 29% had hypercalciuria, and 65% had hyperphosphaturia. There were no significant differences between homozygous and compound heterozygous patients. Ca, P, and Vit-D levels were associated with body mass index; body composition; physical activity; diet; growth hormones; and the immune, liver, and kidney systems. We suggest a periodically evaluation of Ca and P losses.
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
Reference145 articles.
1. Personalized or Precision Medicine? The Example of Cystic Fibrosis;Marson;Front. Pharmacol.,2017 2. Escobedo-Monge, M.F., Barrado, E., Parodi-Román, J., Escobedo-Monge, M.A., Marcos-Temprano, M., and Marugán-Miguelsanz, J.M. (2022). Magnesium Status and Calcium/Magnesium Ratios in a Series of Cystic Fibrosis Patients. Nutrients, 14. 3. Trabecular and cortical bone deficits are present in children and adolescents with cystic fibrosis;Kelly;Bone,2016 4. Jaworska, J., Marach-Mocarska, A., and Sands, D. (2020). Uncommon clinical presentation of cystic fibrosis in a patient homozygous for a rare CFTR mutation: A case report. BMC Pediatr., 20. 5. World Health Organization (2023, March 11). The Molecular Genetic Epidemiology of Cystic Fibrosis. Available online: https://www.who.int/genomics/publications/en/HGN_WB_04.02_report.pdf?ua=1.
|
|