Affiliation:
1. Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai 200241, China
2. Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, School of Life Sciences, East China Normal University, Shanghai 200241, China
Abstract
Skin injury always results in fibrotic, non-functional scars in adults. Although multiple factors are well-known contributors to scar formation, the precise underlying mechanisms remain elusive. This review aims to elucidate the intricacies of the wound healing process, summarize the known factors driving skin cells in wounds toward a scarring fate, and particularly to discuss the impact of fibroblast heterogeneity on scar formation. To the end, we explore potential therapeutic interventions used in the treatment of scarring wounds.
Funder
National Key Research and Development Program of China
Shanghai Municipal Education Commission
National Natural Science Foundation of China
Shanghai Jahwa United Co., Ltd., Shanghai, China
East China Normal University Public Platform for innovation
Instruments Sharing Platform of School of Life Sciences, East China Normal University
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