Level of Disability after Total Hip Replacement in Patients with Some COMT Gene Polymorphism

Author:

Jurewicz Alina1,Dziedziejko Violetta2ORCID,Rać Monika2,Białecka Marta3,Safranow Krzysztof2ORCID,Kurzawski Mateusz3,Malinowski Damian3ORCID,Bosiacki Mateusz4ORCID,Leźnicka Katarzyna5ORCID,Bohatyrewicz Andrzej6,Białecka Monika3,Droździk Marek3ORCID,Machoy-Mokrzyńska Anna3

Affiliation:

1. Department of Specialistic Nursing, Pomeranian Medical University, Żołnierska St. 48, 71-210 Szczecin, Poland

2. Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Al. Powstańców Wielkopolskich 72 St., 70-111 Szczecin, Poland

3. Department of Pharmacology, Pomeranian Medical University, Al. Powstańców Wielkopolskich 72 St., 70-111 Szczecin, Poland

4. Department of Functional Diagnostics and Physical Medicine, Pomeranian Medical University in Szczecin, Żołnierska St. 54, 71-210 Szczecin, Poland

5. Faculty of Physical Education, Gdansk University of Physical Education and Sport, K. Górskiego St. 1, 80-336 Gdansk, Poland

6. Department of Orthopedics, Traumatology and Musculoskeletal Oncology, Pomeranian Medical University, Unii Lubelskiej St. 1, 71-252 Szczecin, Poland

Abstract

Background: The COMT gene encodes the enzyme catechol-O-methyltransferase, which is a key modulator of dopaminergic and adrenergic neurotransmission. Hip osteoarthritis is accompanied by reduced mobility and some level of disability. In our study, we analyzed the association between some COMT gene polymorphisms and reduced mobility in patients after total hip replacement (THR). Methods: The operative procedures were performed on 195 patients with symptomatic and radiologically advanced hip osteoarthritis. In the postoperative follow-up, we assessed hip function with the Harris Hip Score (HHS) and the degree of disability with the Oswestry Disability Index (ODI). These procedures were repeated three times at defined intervals (one week, six weeks, and six months) after the total hip replacement. Genomic DNA was extracted from peripheral blood. SNPs in the COMT genes rs4680:A>G, rs6269:A>G, rs4633:C>T, and rs4818:C>G were genotyped. Results: Our findings suggest an association between COMT gene variability and the level of disability measured by the Oswestry Disability Index (ODI) in patients after total hip replacement (THR). Conclusions: A higher number of COMT G alleles (rs4818) is an independent factor in a significant reduction in disability degree at both one week and six months after total hip replacement (THR), regardless of age or gender.

Publisher

MDPI AG

Subject

General Medicine

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3