Prognostic Role of Pre- and Post-Treatment [18F]FDG PET/CT in Squamous Cell Carcinoma of the Oropharynx in Patients Treated with Chemotherapy and Radiotherapy-Reference-Cited by-同舟云学术

Prognostic Role of Pre- and Post-Treatment [18F]FDG PET/CT in Squamous Cell Carcinoma of the Oropharynx in Patients Treated with Chemotherapy and Radiotherapy

Published:2024-07-29 Issue:3 Volume:12 Page:36
ISSN:2076-3271
Container-title:Medical Sciences
language:en
Short-container-title:Medical Sciences

Author:

Dondi Francesco¹^ORCID,Gazzilli Maria²^ORCID,Albano Domenico¹^ORCID,Rizzo Alessio³^ORCID,Treglia Giorgio⁴⁵⁶^ORCID,Pisani Antonio Rosario⁷^ORCID,Palumbo Carmen⁷,Rubini Dino⁸,Racca Manuela³^ORCID,Rubini Giuseppe⁷^ORCID,Bertagna Francesco¹

Affiliation:

1. Nuclear Medicine, Università degli Studi di Brescia and ASST Spedali Civili di Brescia, 25123 Brescia, Italy

2. Nuclear Medicine, ASL Bari—P.O. Di Venere, 70012 Bari, Italy

3. Department of Nuclear Medicine, Candiolo Cancer Institute, FPO—IRCCS, 10060 Turin, Italy

4. Clinic of Nuclear Medicine, Imaging Institute of Southern Switzerland, Ente Ospedaliero Cantonale, 6501 Bellinzona, Switzerland

5. Faculty of Biology and Medicine, University of Lausanne, 1011 Lausanne, Switzerland

6. Faculty of Biomedical Sciences, Università della Svizzera Italiana, 6900 Lugano, Switzerland

7. Nuclear Medicine Section, Interdisciplinary Department of Medicine, University of Bari “Aldo Moro”, 70124 Bari, Italy

8. Department of Precision Medicine, University of Campania “L. Vanvitelli”, 80138 Naples, Italy

Abstract

Background: The prognostic role of imaging with [18F]fluorodeoxyglucose ([18F]FDG) positron emission tomography/computed tomography (PET/CT) in oropharynx cancer (OPC) has been demonstrated in the past. The aim of this study was to assess the prognostic impact of both baseline and post-treatment PET/CT in patients with OPC and treated with chemo- and/or radiotherapy. Methods: The PET/CT parameters of scans performed before and after therapy were collected and analyzed to find significant prognosticators for progression-free survival (PFS) and overall survival (OS). Human papillomavirus (HPV) infection’s influence on the prognosis was also taken into account. Results: A total of 66 patients were included in the study. The staging volumetric parameters of PET/CT were significant prognosticators for OS, while the same parameters were affordable predictors for PFS at the restaging evaluation. No significant correlations between HPV infection and PET/CT parameters were reported. Conclusion: The prognostic role of volumetric [18F]FDG PET/CT parameters in patients with OPC was reported.

Publisher

MDPI AG

Link

https://www.mdpi.com/2076-3271/12/3/36/pdf

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