Synthesis and Anti-Inflammatory Activity of (Z)-4-(2-(3-Oxopiperazin-2-ylidene)acetyl)benzoic Acid-Reference-Cited by-同舟云学术

Synthesis and Anti-Inflammatory Activity of (Z)-4-(2-(3-Oxopiperazin-2-ylidene)acetyl)benzoic Acid

Published:2024-02-05 Issue:1 Volume:2024 Page:M1772
ISSN:1422-8599
Container-title:Molbank
language:en
Short-container-title:Molbank

Author:

Dmitriev Maksim V.¹^ORCID,Khramtsova Ekaterina E.¹^ORCID,Apuskin Danila Y.¹^ORCID,Andreev Alexander I.¹,Kovalenko Ilya I.¹^ORCID,Mashevskaya Irina V.¹,Maslivets Andrey N.¹^ORCID

Affiliation:

1. Department of Chemistry, Perm State University, ul. Bukireva, 15, 614990 Perm, Russia

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) are an important class of medications; however, they have some drawbacks. We are developing a new NSAID with pronounced anti-inflammatory and analgesic activities and a very low toxicity—(Z)-3-(2-oxo-2-(p-tolyl)ethylidene)piperazin-2-one (piron). In this work, we describe the synthesis of the main metabolite of piron—(Z)-4-(2-(3-oxopiperazin-2-ylidene)acetyl)benzoic acid. The anti-inflammatory activity of the synthesized metabolite was determined in vivo.

Funder

Perm Research and Educational Center “Rational subsoil use”

Publisher

MDPI AG

Link

https://www.mdpi.com/1422-8599/2024/1/M1772/pdf

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